2-(2,4'-difluorobiphenyl-4-yl)-2-hydroxyacetic acid

Base Information

• Chemical Name: 2-(2,4'-difluorobiphenyl-4-yl)-2-hydroxyacetic acid
• CAS No.: 1214328-48-9
• Molecular Formula: C₁₄H₁₀F₂O₃
• Molecular Weight: 264.228
• Mol file: 1214328-48-9.mol

Synonyms:2-(2,4'-difluorobiphenyl-4-yl)-2-hydroxyacetic acid

Chemical Property of 2-(2,4'-difluorobiphenyl-4-yl)-2-hydroxyacetic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2,4'-difluorobiphenyl-4-yl)-2-hydroxyacetic acid

There total 1 articles about 2-(2,4'-difluorobiphenyl-4-yl)-2-hydroxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-( 4-bromo-3-fluorophenyl)acetonitrile (499983-13-0) → 2-(2,4'-difluorobiphenyl-4-yl)-2-hydroxyacetic acid (1214328-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 120 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / 1.03 h / -78 °C / Inert atmosphere

2.2: 3.03 h / -78 °C / Inert atmosphere

3.1: sulfuric acid / water / 3 h / Inert atmosphere; Heating

With sulfuric acid; tetrabutylammomium bromide; tert.-butyl lithium; palladium diacetate; sodium carbonate; In tetrahydrofuran; water; 1.1: Suzuki coupling;

DOI:10.1021/jm101450p

upstream raw materials:

2-( 4-bromo-3-fluorophenyl)acetonitrile

Refernces