C₄₂H₄₀Cl₂N₈O₁₄P₂

Base Information

• Chemical Name: C₄₂H₄₀Cl₂N₈O₁₄P₂
• CAS No.: 85240-03-5
• Molecular Formula: C₄₂H₄₀Cl₂N₈O₁₄P₂
• Molecular Weight: 1013.68
• Mol file: 85240-03-5.mol

Synonyms:C₄₂H₄₀Cl₂N₈O₁₄P₂

Chemical Property of C₄₂H₄₀Cl₂N₈O₁₄P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₄₀Cl₂N₈O₁₄P₂

There total 14 articles about C₄₂H₄₀Cl₂N₈O₁₄P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → C42H40Cl2N8O14P2 (85240-03-5)

Guidance literature:

Multi-step reaction with 5 steps

1: dioxane / 2 h / 20 °C

2: 1-methylimidazole / dioxane / 3 h / 20 °C

3: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

4: 62 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3.5 h / 20 °C

5: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; benzenesulfonic acid; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine; methanol; chloroform;

DOI:10.1002/hlca.19820650803

Reference yield:

C63H58Cl2N8O16P2 (78098-91-6) → C42H40Cl2N8O14P2 (85240-03-5)

Guidance literature:

With benzenesulfonic acid; In methanol; chloroform; at 0 ℃; for 0.25h; Yield given;

DOI:10.1002/hlca.19820650803

Reference yield:

N-benzoyl-3',5'-di-O-benzoyl-2'-deoxyadenosine (64723-02-0) → C42H40Cl2N8O14P2 (85240-03-5)

Guidance literature:

Multi-step reaction with 7 steps

1: NaOH / pyridine; ethanol; H₂O / 0.25 h

2: 1.) pyridine, 0 deg C, 16 h, 2.) pyridine, CH₃OH, 20 deg C, 1 h

3: dioxane / 2 h / 20 °C

4: 1-methylimidazole / dioxane / 3 h / 20 °C

5: triethylamine / pyridine / 3 h / 20 °C

6: 62 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3.5 h / 20 °C

7: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

With sodium hydroxide; 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; triethylamine; benzenesulfonic acid; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine; methanol; ethanol; chloroform; water;

DOI:10.1002/hlca.19820650803

upstream raw materials:

C₆₃H₅₈Cl₂N₈O₁₆P₂

Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

N-benzoyl-3',5'-di-O-benzoyl-2'-deoxyadenosine

5'-O-(dimethoxytrityl)thymidine 3'-(o-chlorophenyl β-cyanoethyl phosphate)

Refernces