α-methoxy-p-chloropropiophenone

Base Information

• Chemical Name: α-methoxy-p-chloropropiophenone
• CAS No.: 90919-32-7
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.649
• Mol file: 90919-32-7.mol

Synonyms:α-methoxy-p-chloropropiophenone

Chemical Property of α-methoxy-p-chloropropiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-methoxy-p-chloropropiophenone

There total 10 articles about α-methoxy-p-chloropropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 4'-chloropropiophenone (6285-05-8) → α-methoxy-p-chloropropiophenone (90919-32-7)

Guidance literature:

With p-nitrobenzenesulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In acetonitrile; at 80 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201500006

Reference yield: 86.0%

C18H29ClOSi + 4-cyano-1-methoxypyridin-1-ium tetrafluoroborate → α-methoxy-p-chloropropiophenone (90919-32-7)

Guidance literature:

With dipotassium hydrogenphosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In acetonitrile; at 20 ℃; for 18h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03444

Reference yield: 30.0%

2-chloro-1-(4-chlorophenyl)propan-1-one (126918-29-4,877-38-3) → 4'-chloropropiophenone (6285-05-8) + methyl 2-(p-chlorophenyl)propionate (50415-70-8) + α-methoxy-p-chloropropiophenone (90919-32-7)

Guidance literature:

With methyloxirane; In methanol; Irradiation; pH neutral;

DOI:10.1016/S0040-4020(01)80835-8

upstream raw materials:

2-bromo-1-(4-chlorophenyl)-1-propanone

sodium methylate

2-chloro-1-(4-chlorophenyl)propan-1-one

2-methoxy-propanenitrile

Downstream raw materials:

(R)-(+)-1-(4-chlorophenyl)-2-hydroxypropan-1-one

α-acetoxy-p-chloropropiophenone

1-(4-chlorophenyl)-2-hydroxypropan-1-one

Refernces

• 1、 Zhu, Cuiju,Zhang, Yuanfei,Zhao, Huaiqing,Huang, Shijun,Zhang, Min,Su, Weiping. "Sodium iodide-catalyzed direct α-alkoxylation of ketones with alcohols via oxidation of α-iodo ketone intermediates". supporting information. p. 331 - 338. Retrieved 2015/02/19.
• 2、 Sonawane, Harikisan,Bellur, Nanjundiah S.,Kulkarni, Dilip G.,Ayyangar, Nagaraj R.. "Photochemical Rearrangement of α-Chloro-Propiophenones to α-Arylpropanoic Acids: Studies on Chirality Transfer and Synthesis of (S)-(+)-Ibuprofen and (S)-(+)-Ketoprofen". . p. 1243 - 1260. Retrieved 2007/10/02.