Technology Process of 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine
There total 11 articles about 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine;
With
hydrogen; triethylamine;
palladium 10% on activated carbon;
In
methanol;
for 4h;
trifluoroacetic anhydride;
With
pyridine;
at 0 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1,2,3-triazole; triethylamine; trichlorophosphate / acetonitrile / 3.33 h / 0 - 20 °C
2.1: triethylamine / dichloromethane / 18 h / 20 °C
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / Cooling with ice
4.1: triethylamine / ethanol / 8 h / 90 °C
4.2: 3 h / 20 °C
5.1: pyridine / 4 h / 20 °C
6.1: hydrogen; triethylamine / palladium 10% on activated carbon / methanol / 4 h
7.1: trifluoroacetic anhydride / pyridine
With
1,2,3-triazole; di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic anhydride; trichlorophosphate;
palladium 10% on activated carbon;
In
pyridine; methanol; ethanol; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 18 h / 20 °C
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / Cooling with ice
3.1: triethylamine / ethanol / 8 h / 90 °C
3.2: 3 h / 20 °C
4.1: pyridine / 4 h / 20 °C
5.1: hydrogen; triethylamine / palladium 10% on activated carbon / methanol / 4 h
6.1: trifluoroacetic anhydride / pyridine
With
di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic anhydride;
palladium 10% on activated carbon;
In
pyridine; methanol; ethanol; dichloromethane;
