Technology Process of 3,3-Bis(4-fluorophenyl)-1-(2-oxo-2-piperazin-1-ylethyl)piperidin-2-one
There total 6 articles about 3,3-Bis(4-fluorophenyl)-1-(2-oxo-2-piperazin-1-ylethyl)piperidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium hydroxide, 20 wt% on carbon;
In
tetrahydrofuran;
at 50 ℃;
for 0.25h;
under 1551.49 Torr;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium ethanolate / 1,4-dioxane / 0.5 h / 40 - 45 °C
1.2: 1 h / 60 - 70 °C
2.1: hydrogen; ammonia / methanol / 24 h / 20 °C / 1551.49 Torr
3.1: potassium tert-butylate / tetrahydrofuran / 80 °C / Inert atmosphere
4.1: water; lithium hydroxide / ethanol / 2 h / 80 °C
5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere
6.1: hydrogen / palladium hydroxide, 20 wt% on carbon / tetrahydrofuran / 0.25 h / 50 °C / 1551.49 Torr
With
dmap; potassium tert-butylate; ammonia; water; hydrogen; sodium ethanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
palladium hydroxide, 20 wt% on carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogen; ammonia / methanol / 24 h / 20 °C / 1551.49 Torr
2: potassium tert-butylate / tetrahydrofuran / 80 °C / Inert atmosphere
3: water; lithium hydroxide / ethanol / 2 h / 80 °C
4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere
5: hydrogen / palladium hydroxide, 20 wt% on carbon / tetrahydrofuran / 0.25 h / 50 °C / 1551.49 Torr
With
dmap; potassium tert-butylate; ammonia; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
palladium hydroxide, 20 wt% on carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;