(R)-2-Amino-2-methylbutanoic acid hydrochloride

Base Information

• Chemical Name: (R)-2-Amino-2-methylbutanoic acid hydrochloride
• CAS No.: 73473-40-2
• Molecular Formula: C5H11 N O2 . Cl H
• Molecular Weight: 153.609
• Hs Code.: 2922498590
• European Community (EC) Number: 805-437-8
• DSSTox Substance ID: DTXSID30592120
• Metabolomics Workbench ID: 68033
• Mol file: 73473-40-2.mol

Synonyms:73473-40-2;(R)-2-Amino-2-methylbutanoic acid hydrochloride;D(-)-Isovaline;(R)-2-Amino-2-methylbutyric acid hydrochloride;(2R)-2-amino-2-methylbutanoic acid hydrochloride;(2R)-2-amino-2-methylbutanoic acid;hydrochloride;3059-97-0;(R)-2-Amino-2-methylbutyric acid, HCl;(R)-2-AMINO-2-METHYL-BUTYRIC ACID HYDROCHLORIDE;isovaline-HCl;(R)-2-Amino-2-methylbutyric acid HCl;(2R)-2-Amino-2-methyl-butanoic acid hydrochloride;SCHEMBL9900847;DTXSID30592120;CYBOBNODYVJFNM-NUBCRITNSA-N;AKOS017343942;D-Isovaline--hydrogen chloride (1/1);SB17730;(R)-2-Amino-2-methylbutanoicacidhydrochloride;(R)-2-amino-2-methyl-butanoic acid hydrochloride

Chemical Property of (R)-2-Amino-2-methylbutanoic acid hydrochloride

Chemical Property:

• PSA: 63.32000
• LogP: 1.70070
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 153.0556563
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-2-Amino-2-methylbutanoicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)(C(=O)O)N.Cl
• Isomeric SMILES: CC[C@](C)(C(=O)O)N.Cl

Technology Process of (R)-2-Amino-2-methylbutanoic acid hydrochloride

There total 4 articles about (R)-2-Amino-2-methylbutanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4R)-3-benzoyl-4-ethyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one (118995-18-9,1279025-92-1) → benzaldehyde (100-52-7) + (2R)-2-amino-2-methylbutanoic acid hydrochloride (73473-40-2) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With hydrogenchloride; for 3h; Yield given; Heating;

DOI:10.1016/S0040-4020(01)86182-2

Reference yield:

(2R)-2-amino-2-methylbutanoic acid (3059-97-0,465-58-7) → (2R)-2-amino-2-methylbutanoic acid hydrochloride (73473-40-2)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 25h; pH=4;

DOI:10.1016/j.tetasy.2014.11.011

Reference yield:

(R)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid (123254-58-0) → (2R)-2-amino-2-methylbutanoic acid hydrochloride (73473-40-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1021/jo990957o

upstream raw materials:

2-<(2S)-2-Methoxymethyl-1-pyrrolidinylmethyleneamino>-2-methylbutanoic acid, methyl ester

(2S,4R)-3-benzoyl-4-ethyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one

(R)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid

(2R)-2-amino-2-methylbutanoic acid

Downstream raw materials:

(R)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid

(R)-methyl 2-(amino)-2-methylbutanoate

Refernces

• 1、 Avenoza, Alberto,Cativiela, Carlos,Corzana, Francisco,Peregrina, Jesus M.,Zurbano, Maria M.. "Preparation and synthetic applications of (S)- and (R)-N-boc-N, O- isopropylidene-α-methylserinals: Asymmetric synthesis of (S)- and (R)-2- amino-2-methylbutanoic acids (Iva)". . p. 8220 - 8225. Retrieved 2007/10/03.
• 2、 Kolb, Michael,Barth, Jacqueline. "Asymmetric Synthesis of α-Substituted Amino Acids and Amines by Carbon-Carbon Bond Formation in Position α to the Nitrogen". . p. 1668 - 1688. Retrieved 2007/10/02.