[3-(4-Fluorophenyl)phenyl]methanol

Base Information

• Chemical Name: [3-(4-Fluorophenyl)phenyl]methanol
• CAS No.: 773871-79-7
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.228
• Hs Code.: 2906299090
• European Community (EC) Number: 831-817-8
• DSSTox Substance ID: DTXSID00362650
• Wikidata: Q82145931
• Mol file: 773871-79-7.mol

Synonyms:[3-(4-fluorophenyl)phenyl]methanol;773871-79-7;(4'-Fluoro-[1,1'-biphenyl]-3-yl)methanol;(4'-Fluoro[1,1'-biphenyl]-3-yl)methanol;(4'-Fluorobiphenyl-3-yl)-methanol;SCHEMBL20677885;DTXSID00362650;MFCD05980493;AKOS002683448;BB 0224055;CS-0190248;E89815;EN300-6245403;A1-00991

Chemical Property of [3-(4-Fluorophenyl)phenyl]methanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.98500
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 202.079393132
• Heavy Atom Count: 15
• Complexity: 187

Purity/Quality:

99%min ^*data from raw suppliers

(4'-FLUOROBIPHENYL-3-YL)-METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)C2=CC=C(C=C2)F)CO

Technology Process of [3-(4-Fluorophenyl)phenyl]methanol

There total 6 articles about [3-(4-Fluorophenyl)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3-Bromophenyl)methanol (15852-73-0) + 4-fluoroboronic acid (1765-93-1) → (4′-fluoro-[1,1′-biphenyl]-3-yl)methanol (773871-79-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; for 5h; Inert atmosphere; Reflux;

Reference yield: 96.4%

4'-fluoro-[1,1'-biphenyl]-3-carbaldehyde (164334-74-1) → (4′-fluoro-[1,1′-biphenyl]-3-yl)methanol (773871-79-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; 1,2-dimethoxyethane; for 3h; Cooling with ice;

Reference yield: 77.0%

3-iodobenzylalcohol (57455-06-8) + tris(4-fluorophenyl)bismuthane (437-29-6) → (4′-fluoro-[1,1′-biphenyl]-3-yl)methanol (773871-79-7)

Guidance literature:

With tetrabutylammomium bromide; potassium acetate; palladium diacetate; tris-(o-tolyl)phosphine; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 4h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.151676

upstream raw materials:

4'-fluoro-3-methyl-1,1'-biphenyl

(3-Bromophenyl)methanol

4-fluoroboronic acid

m-bromobenzoic aldehyde

Refernces

• 1、 -. "THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION". Paragraph 0432-0433. . Retrieved 2019/02/13.