2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine

Base Information

• Chemical Name: 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine
• CAS No.: 77211-73-5
• Molecular Formula: C₁₄H₂₁N₃O₂
• Molecular Weight: 263.34
• Mol file: 77211-73-5.mol

Synonyms:2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine

Chemical Property of 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine

There total 2 articles about 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetate (67281-07-6) → 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine (77211-73-5)

Guidance literature:

With hydrazine hydrate; at 100 ℃; for 2h;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine (77211-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to 20 deg C

2: 58 percent / 80percent hydrazine hydrate / 2 h / 100 °C

With n-butyllithium; hydrazine hydrate; diisopropylamine;

DOI:10.1021/jm00143a012

Reference yield: 72.4%

2-(1-benzyl-4-hydroxypiperidin-4-yl)acetyl hydrazine (77211-73-5) → 8-Benzyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one (5053-14-5)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 10 - 60 ℃; for 0.333333h; pH=2 - 3;

upstream raw materials:

ethyl 2-(1-benzyl-4-hydroxypiperidin-4-yl)acetate

1-phenylmethyl-4-piperidone

Downstream raw materials:

8-Benzyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

Refernces

• 1、 Caroon,Clark,Kluge,Nelson,Strosberg,Unger,Michel,Whiting. "Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3,8-diazaspiro[4,5]decan-2-ones". . p. 1320 - 1328. Retrieved 2007/10/02.