ethyl 2-(2,6-dichlorophenyl)acetate

Base Information

• Chemical Name: ethyl 2-(2,6-dichlorophenyl)acetate
• CAS No.: 90793-64-9
• Molecular Formula: C₁₀H₁₀Cl₂O₂
• Molecular Weight: 233.094
• Mol file: 90793-64-9.mol

Synonyms:ethyl 2-(2,6-dichlorophenyl)acetate

Chemical Property of ethyl 2-(2,6-dichlorophenyl)acetate

Chemical Property:

• Boiling Point: 289.0±25.0 °C(Predicted)
• Density: 1.276±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

(2,6-Dichlorophenyl)aceticacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ethyl 2-(2,6-Dichlorophenyl)acetate is used in preparation of heteroarylaminonaphthyridinone derivatives for use as multiple kinase pathway inhibitors.

Technology Process of ethyl 2-(2,6-dichlorophenyl)acetate

There total 3 articles about ethyl 2-(2,6-dichlorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 2,6-dichlorotoluene (118-69-4) → ethyl 2-(2,6-dichlorophenyl)acetate (90793-64-9)

Guidance literature:

With di-tert-butyl peroxide; dichloro[4,5-bis(diphenylphosphino)-9,9’-dimethylxanthene]palladium(II); at 120 ℃; for 16h; under 7600.51 Torr;

Reference yield:

ethanol (64-17-5) + 2-(2,6-dichlorophenyl)acetic acid (6575-24-2) → ethyl 2-(2,6-dichlorophenyl)acetate (90793-64-9)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1016/0957-4166(94)80086-3

Reference yield:

→ ethyl 2-(2,6-dichlorophenyl)acetate (90793-64-9)

Guidance literature:

Phenyl-2-(dichlor-2',6'-benzyliden)-4-oxazolon-5, EtOH;

upstream raw materials:

ethanol

2-(2,6-dichlorophenyl)acetic acid

carbon monoxide

2,6-dichlorotoluene

Downstream raw materials:

[2-(2,6-dichloro-benzyl)-pyrrolidin-1-yl]-(3-difluoromethyl-1-methyl-1H-pyrazol-4-yl)-methanone

2-(2,6-dichloro-benzyl)-pyrrolidine

5-(2,6-dichloro-benzyl)-3,4-dihydro-2H-pyrrole

7-chloro-3-(2,6-dichlorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

Refernces

• 1、 -. "PROCESS FOR SYNTHESIZING PHENYLACETIC ACID BY CARBONYLATION OF TOLUENE". Paragraph 0070; 0071. . Retrieved 2013/11/19.
• 2、 Gao, Yunlong,Zhao, Guilong,Liu, Wei,Wang, Yuli,Xu, Weiren,Wang, Jianwu. "Thiadiazole-based Thioglycosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors". scheme or table. p. 605 - 612. Retrieved 2010/10/19.