Z-Ala-O-COO-isoBu

Base Information

• Chemical Name: Z-Ala-O-COO-isoBu
• CAS No.: 25172-67-2
• Molecular Formula: C₁₆H₂₁NO₆
• Molecular Weight: 323.346
• Mol file: 25172-67-2.mol

Synonyms:Z-Ala-O-COO-isoBu

Chemical Property of Z-Ala-O-COO-isoBu

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-Ala-O-COO-isoBu

There total 1 articles about Z-Ala-O-COO-isoBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Cbz-Ala (1142-20-7) + isobutyl chloroformate (543-27-1) → Z-Ala-O-COO-isoBu (25172-67-2)

Guidance literature:

With triethylamine; In ethyl acetate; at -12 ℃;

DOI:10.1021/jo00268a020

Reference yield:

Z-Ala-O-COO-isoBu (25172-67-2) → L-alanyl-L-valine (1472-66-8,1999-46-8,3303-45-5,3303-46-6,61427-69-8,99146-59-5)

Guidance literature:

Z-Ala-O-COO-isoBu; (S)-Val ester salt; With 4-methyl-morpholine; In dichloromethane; at -15 - 20 ℃;

With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 4654.46 Torr; Further stages.;

DOI:10.1002/chem.200501639

Reference yield:

Z-Ala-O-COO-isoBu (25172-67-2) → alanylglycine (687-69-4)

Guidance literature:

Z-Ala-O-COO-isoBu; Gly ester salt; With 4-methyl-morpholine; In dichloromethane; at -15 - 20 ℃;

With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 4654.46 Torr; Further stages.;

DOI:10.1002/chem.200501639

upstream raw materials:

N-Cbz-Ala

isobutyl chloroformate

Downstream raw materials:

N-(benzyloxycarbonyl)-L-alanyl-L-serine methyl ester

methyl S-<<<2-<(benzyloxycarbonyl)-L-alanyloxy>-5-chlorophenyl>methyl>thio>-L-cysteinate hydrochloride

Z-Ala-Glu(OtBu)-Phe-OMe

N-carbobenzoxy-5,6-O-isopropylidene-5,6,10-triepi-actinobolin

Refernces

• 1、 Chuck, Chi-Pang,Chen, Chao,Ke, Zhihai,Chi-Cheong Wan, David,Chow, Hak-Fun,Wong, Kam-Bo. "Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases". . p. 1 - 6. Retrieved 2013/03/13.
• 2、 Verardo, Giancarlo,Gorassini, Andrea. "Sodium borohydride reduction of carbamoyl azide function: A synthesis of N-protected N'-formyl-gem-diaminoalkyl derivatives". . p. 5387 - 5397. Retrieved 2013/09/02.