Pyrrolidine, 1-[3-(butylthio)-1-thioxopropyl]- (9CI)

Base Information

• Chemical Name: Pyrrolidine, 1-[3-(butylthio)-1-thioxopropyl]- (9CI)
• CAS No.: 73199-97-0
• Molecular Formula: C₁₁H₂₁NS₂
• Molecular Weight: 231.426
• Mol file: 73199-97-0.mol

Synonyms:Pyrrolidine,1-[3-(butylthio)-1-thioxopropyl]- (9CI)

Chemical Property of Pyrrolidine, 1-[3-(butylthio)-1-thioxopropyl]- (9CI)

Chemical Property:

• PSA: 60.63000
• LogP: 3.27090

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrrolidine, 1-[3-(butylthio)-1-thioxopropyl]- (9CI)

There total 2 articles about Pyrrolidine, 1-[3-(butylthio)-1-thioxopropyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-<3-(Butylthio)propanoyl>azacyclopentane (73199-87-8) → 1-<3-(Butylthio)propanethioyl>azacyclopentane (73199-97-0)

Guidance literature:

With diphosphorus pentasulfide; In xylene; for 1h; Heating;

DOI:10.1021/jo01298a022

Reference yield:

3-(butylthio)propionic acid (22002-73-9) → 1-<3-(Butylthio)propanethioyl>azacyclopentane (73199-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) thionyl chloride, dimethylformamide / 1.) room temperature, 16 h, 2.) dichloromethane, added over 30 min to ice-cold solution, then room temperature, 1 h

2: 63 percent / phosphorus pentasulfide / xylene / 1 h / Heating

With diphosphorus pentasulfide; thionyl chloride; N,N-dimethyl-formamide; In xylene;

DOI:10.1021/jo01298a022

upstream raw materials:

1-<3-(Butylthio)propanoyl>azacyclopentane

3-(butylthio)propionic acid

Refernces