Boc-Gly-L-Phe-L-Cys-Gly-OCH₃

Base Information

• Chemical Name: Boc-Gly-L-Phe-L-Cys-Gly-OCH₃
• CAS No.: 1340584-92-0
• Molecular Formula: C₂₂H₃₂N₄O₇S
• Molecular Weight: 496.585
• Mol file: 1340584-92-0.mol

Synonyms:Boc-Gly-L-Phe-L-Cys-Gly-OCH₃

Chemical Property of Boc-Gly-L-Phe-L-Cys-Gly-OCH₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Gly-L-Phe-L-Cys-Gly-OCH₃

There total 7 articles about Boc-Gly-L-Phe-L-Cys-Gly-OCH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(Boc-Gly-L-Phe-L-Cys-Gly-OCH3)2 (1340584-91-9) → Boc-Gly-L-Phe-L-Cys-Gly-OCH3 (1340584-92-0)

Guidance literature:

With tributylphosphine; water; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c1ob05740e

Reference yield:

{2-amino-3-[2-amino-2-(methoxycarbonylmethylcarbamoyl)ethyldisulfanyl]propionylamino}acetic acid methyl ester dihydrochloride → Boc-Gly-L-Phe-L-Cys-Gly-OCH3 (1340584-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine / tetrahydrofuran; N,N-dimethyl-formamide / -10 - 20 °C / Inert atmosphere

2: tributylphosphine; water / methanol / 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; tributylphosphine; water; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1039/c1ob05740e

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → Boc-Gly-L-Phe-L-Cys-Gly-OCH3 (1340584-92-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / water; acetonitrile / 2 h / 25 °C

2: 4-methyl-morpholine / tetrahydrofuran / -10 °C / Inert atmosphere

3: 4-methyl-morpholine / tetrahydrofuran; N,N-dimethyl-formamide / -10 - 20 °C / Inert atmosphere

4: tributylphosphine; water / methanol / 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; tributylphosphine; water; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c1ob05740e

upstream raw materials:

(Boc-Gly-L-Phe-L-Cys-Gly-OCH₃)2

L-phenylalanine

N-t-butyloxycarbonylglycyl-L-phenylalanine

(6R,11R)-methyl 11-((tert-butoxycarbonyl)amino)-6-((2-methoxy-2-oxoethyl)carbamoyl)-2,2-dimethyl-4,12-dioxo-3-oxa-8,9-dithia-5,13-diazapentadecan-15-oate

Downstream raw materials:

H-Gly-L-Phe-L-Cys(S-Cbz-L-Ala)-Gly-OCH₃ hydrochloride

C₂₈H₃₅N₅O₈S

C₃₉H₄₆N₆O₁₁S

Boc-Gly-L-Phe-L-Cys(S-Cbz-L-Ala)-Gly-OCH₃

Refernces