2-bromo-5-chlorobenzoyl chloride

Base Information

• Chemical Name: 2-bromo-5-chlorobenzoyl chloride
• CAS No.: 42860-16-2
• Molecular Formula: C₇H₃BrCl₂O
• Molecular Weight: 253.91
• Hs Code.: 2916399090
• Mol file: 42860-16-2.mol

Synonyms:2-bromo-5-chlorobenzoyl chloride

Chemical Property of 2-bromo-5-chlorobenzoyl chloride

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

2-Bromo-5-chlorobenzoylchloride 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-5-chlorobenzoyl chloride

There total 3 articles about 2-bromo-5-chlorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-5-chlorobenzoic acid (21739-93-5) → 2-bromo-5-chlorobenzoyl chloride (42860-16-2)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 70 ℃; for 25.5h; Inert atmosphere;

DOI:10.1002/anie.201914864

Reference yield:

5-chloro-2-nitrobenzoic acid (2516-95-2) → 2-bromo-5-chlorobenzoyl chloride (42860-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Sn; HCl / man ersetzt in der entstandenen Chloraminobenzoesaeure die NH₂-Gruppe nach dem Sandmeyerschen Verfahren durch Brom

2: PCl₅ / 130 - 140 °C

With hydrogenchloride; tin; phosphorus pentachloride;

Reference yield:

2-bromo-5-chlorotoluene (14495-51-3) → 2-bromo-5-chlorobenzoyl chloride (42860-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₃

2: PCl₅ / 130 - 140 °C

With phosphorus pentachloride; nitric acid;

upstream raw materials:

2-bromo-5-chlorobenzoic acid

5-chloro-2-nitrobenzoic acid

2-bromo-5-chlorotoluene

Downstream raw materials:

2-bromo-5,3'-dichloro-benzophenone

2-(2-bromo-5-chloro-phenyl)acetic acid

Refernces

• 1、 Suginome, Michinori,Yamamoto, Takeshi,Yoshinaga, Yukako. "Stereoinvertive C–C Bond Formation at the Boron-Bound Stereogenic Centers through Copper-Bipyridine-Catalyzed Intramolecular Coupling of α-Aminobenzylboronic Esters". supporting information. p. 7251 - 7255. Retrieved 2020/03/23.
• 2、 Li, Xiang,Zhou, Bo,Yang, Run-Ze,Yang, Fu-Ming,Liang, Ren-Xiao,Liu, Ren-Rong,Jia, Yi-Xia. "Palladium-Catalyzed Enantioselective Intramolecular Dearomative Heck Reaction". supporting information. p. 13945 - 13951. Retrieved 2018/10/20.