O¹-Phosphono-α-D-arabinofuranose

Base Information

• Chemical Name: O¹-Phosphono-α-D-arabinofuranose
• CAS No.: 72075-46-8
• Molecular Formula: C₅H₁₁O₈P
• Molecular Weight: 230.111
• Mol file: 72075-46-8.mol

Synonyms:O¹-Phosphono-α-D-arabinofuranose

Chemical Property of O¹-Phosphono-α-D-arabinofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O¹-Phosphono-α-D-arabinofuranose

There total 6 articles about O¹-Phosphono-α-D-arabinofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-iodouridine (1024-99-3) → ribofuranose-1-phosphate (18646-11-2,19993-20-5,21317-51-1,27638-61-5,50574-24-8,51501-98-5,72075-46-8,98243-09-5,119240-26-5,14075-00-4) + 5-iodouracil (696-07-1)

Guidance literature:

With recombinant thymidine phosphorylase from Mycoplasma hyorhinis; at 37 ℃; for 0.333333h; Kinetics; aq. buffer; Enzymatic reaction;

DOI:10.1042/BJ20112225

Reference yield:

5-fluorouridine (316-46-1) → 5-fluorouracil (51-21-8) + ribofuranose-1-phosphate (18646-11-2,19993-20-5,21317-51-1,27638-61-5,50574-24-8,51501-98-5,72075-46-8,98243-09-5,119240-26-5,14075-00-4)

Guidance literature:

With recombinant thymidine phosphorylase from Mycoplasma hyorhinis; at 37 ℃; for 0.333333h; Kinetics; aq. buffer; Enzymatic reaction;

DOI:10.1042/BJ20112225

Reference yield:

Fludarabine (146-78-1,19768-92-4,21679-14-1,21679-15-2) → 2-fluoroadenine (700-49-2) + O1-Phosphono-α-D-arabinofuranose (72075-46-8)

Guidance literature:

With E_. coli purine nucleoside phosphorylase; Enzyme kinetics;

DOI:10.1080/15257779908041562

upstream raw materials:

Fludarabine

Hypoxanthine arabinoside

Inosine

5-fluorouridine

Downstream raw materials:

8-azaguanosine

Refernces

• 1、 Secrist III, John A.. "Gene therapy of cancer: activation of nucleoside prodrugs with e. colipurine nucleoside phosphorylase". . p. 745 - 757. Retrieved 2007/10/03.