6-Methylphthalazine

Base Information

• Chemical Name: 6-Methylphthalazine
• CAS No.: 78032-05-0
• Molecular Formula: C9H8 N2
• Molecular Weight: 144.176
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10506644
• Nikkaji Number: J2.642.449F
• Wikidata: Q72495490
• Mol file: 78032-05-0.mol

Synonyms:6-Methylphthalazine;78032-05-0;6-Methyl Phthalazine;SCHEMBL2616769;NPOVJYAUMRFAQD-UHFFFAOYSA-;DTXSID10506644;NPOVJYAUMRFAQD-UHFFFAOYSA-N;MFCD03844800;AKOS015842078;AS-57193;FT-0672024;M1394;T72939;A865107;InChI=1/C9H8N2/c1-7-2-3-8-5-10-11-6-9(8)4-7/h2-6H,1H3

Chemical Property of 6-Methylphthalazine

Chemical Property:

• Vapor Pressure: 0.000185mmHg at 25°C
• Melting Point: 72℃
• Refractive Index: 1.633
• Boiling Point: 339°C at 760 mmHg
• PKA: 3.70±0.30(Predicted)
• Flash Point: 163.8°C
• PSA: 25.78000
• Density: 1.141
• LogP: 1.93820
• Solubility.: soluble in Methanol
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 144.068748264
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-MethylPhthalazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=CN=NC=C2C=C1
• Uses: 6-Methyl Phthalazine is a phthalazine derivative used as melanin biosynthesis inhibitor.

Technology Process of 6-Methylphthalazine

There total 1 articles about 6-Methylphthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

N-[1-p-Tolyl-meth-(Z)-ylidene]-N'-[1-p-tolyl-meth-(E)-ylidene]-hydrazine (4702-76-5,139030-29-8) → 6-methylphthalazine (78032-05-0) + toluene (108-88-3,15644-74-3,16713-13-6)

Guidance literature:

With aluminium trichloride; at 170 - 200 ℃;

DOI:10.1016/0040-4039(81)80093-7

Reference yield:

(furan-2-yloxy)-trimethylsilane (61550-02-5) + 6-methylphthalazine (78032-05-0) → 5-methyl-1a,7b-dihydro-1H-cyclopropa[a]naphthalene-1-carboxylic acid + 6-methyl-1a,7b-dihydro-1H-cyclopropa[a]naphthalene-1-carboxylic acid

Guidance literature:

With 9,10-dimethyl-9,10-dibora-9,10-dihydroanthracene; In diethylene glycol dimethyl ether; at 1450 ℃; for 84h; Overall yield = 92 %; Overall yield = 72.6 mg; Inert atmosphere;

DOI:10.1021/ja308858y

Reference yield:

pyrrolidine (123-75-1) + 3-phenyl-propionaldehyde (104-53-0) + 6-methylphthalazine (78032-05-0) → C22H25N + C22H25N

Guidance literature:

With 9,10-dimethyl-9,10-dibora-9,10-dihydroanthracene; In tetrahydrofuran; at 60 ℃; for 15h; Overall yield = 82 %; Overall yield = 62.2 mg; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.8b02967

upstream raw materials:

N-[1-p-Tolyl-meth-(Z)-ylidene]-N'-[1-p-tolyl-meth-(E)-ylidene]-hydrazine

Refernces