tert-butyl cyano[4-(trifluoromethoxy)phenyl]acetate

Base Information

• Chemical Name: tert-butyl cyano[4-(trifluoromethoxy)phenyl]acetate
• CAS No.: 1104643-47-1
• Molecular Formula: C₁₄H₁₄F₃NO₃
• Molecular Weight: 301.265
• Mol file: 1104643-47-1.mol

Synonyms:tert-butyl cyano[4-(trifluoromethoxy)phenyl]acetate

Chemical Property of tert-butyl cyano[4-(trifluoromethoxy)phenyl]acetate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of tert-butyl cyano[4-(trifluoromethoxy)phenyl]acetate

There total 1 articles about tert-butyl cyano[4-(trifluoromethoxy)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

di-tert-butyl dicarbonate (24424-99-5) + (4-trifluoromethoxy-phenyl)-acetonitrile (49561-96-8) → tert-butyl cyano[4-(trifluoromethoxy)phenyl]acetate (1104643-47-1)

Guidance literature:

(4-trifluoromethoxy-phenyl)-acetonitrile; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1.16667h;

di-tert-butyl dicarbonate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

DOI:10.1016/j.tet.2008.10.089

upstream raw materials:

di-tert-butyl dicarbonate

(4-trifluoromethoxy-phenyl)-acetonitrile

Refernces