(S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

Base Information Edit

Chemical Name:(S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione
CAS No.:149648-97-5
Molecular Formula:C₁₂H₁₄N₂O₃
Molecular Weight:234.255
Hs Code.:
Mol file:149648-97-5.mol

Synonyms:(S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

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Chemical Property of (S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione Edit

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Technology Process of (S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

There total 3 articles about (S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.44%

: 100-46-9
benzylamine

: 366003-57-8
(+)-(2S)-methyl 2-(2-chloroacetylamino)-3-hydroxypropanoate

: 149648-97-5
(S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

Guidance literature:: (+)-(2S)-methyl 2-(2-chloroacetylamino)-3-hydroxypropanoate; With triethylamine; In methanol; for 0.0833333h; Cooling with ice;

benzylamine; In methanol; Reflux;

Reference yield:

: 149648-96-4
N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester

: 149648-97-5
(S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

Guidance literature:: With ammonium hydroxide; thionyl chloride; Yield given. Multistep reaction; 1.) methanol, RT, 2 h, 2.) methanol;
DOI:10.1021/jm00067a004

Reference yield:

: 76315-01-0
N-benzyl-N-(tert-butoxycarbonyl)glycine

: 149648-97-5
(S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, pentafluorophenol, 2.) Et₃N / 1.) dichloromethane, RT, 3 h, 2.) dichloromethane, RT, 20 h

2: 1.) SOCl₂, 2.) aq. NH₃ / 1.) methanol, RT, 2 h, 2.) methanol

With ammonium hydroxide; thionyl chloride; 2,3,4,5,6-pentafluorophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
DOI:10.1021/jm00067a004