4-Hydroxy-4-phenyl-pentanoic acid dimethylamide

Base Information

• Chemical Name: 4-Hydroxy-4-phenyl-pentanoic acid dimethylamide
• CAS No.: 88730-10-3
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 88730-10-3.mol

Synonyms:4-Hydroxy-4-phenyl-pentanoic acid dimethylamide

Chemical Property of 4-Hydroxy-4-phenyl-pentanoic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Hydroxy-4-phenyl-pentanoic acid dimethylamide

There total 4 articles about 4-Hydroxy-4-phenyl-pentanoic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

dimethyl amine (124-40-3) + C11H12N2O (88730-09-0) → 4-Hydroxy-4-phenyl-pentanoic acid dimethylamide (88730-10-3) + 5-methyl-5-phenyl-dihydro-furan-2-one (7210-42-6,21303-80-0,69854-29-1,88314-79-8)

Guidance literature:

DOI:10.1021/ja00317a068

Reference yield:

1-Amino-5-methyl-5-phenyl-pyrrolidin-2-one (88730-06-7) → 4-Hydroxy-4-phenyl-pentanoic acid dimethylamide (88730-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tert-butyl hypochlorite, 2,6-lutidine / diethyl ether

2: 50 percent

With 2,6-dimethylpyridine; tert-butylhypochlorite; In diethyl ether;

DOI:10.1021/ja00317a068

Reference yield:

4-Hydroxy-4-phenyl-pentanoic acid hydrazide (88730-04-5) → 4-Hydroxy-4-phenyl-pentanoic acid dimethylamide (88730-10-3)

Guidance literature:

Multi-step reaction with 3 steps

1: concentrated sulfuric acid / CH₂Cl₂

2: tert-butyl hypochlorite, 2,6-lutidine / diethyl ether

3: 50 percent

With 2,6-dimethylpyridine; tert-butylhypochlorite; sulfuric acid; In diethyl ether; dichloromethane;

DOI:10.1021/ja00317a068

upstream raw materials:

dimethyl amine

C₁₁H₁₂N₂O

1-Amino-5-methyl-5-phenyl-pyrrolidin-2-one

4-Hydroxy-4-phenyl-pentanoic acid hydrazide

Refernces