(3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide

Base Information

• Chemical Name: (3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide
• CAS No.: 1047671-76-0
• Molecular Formula: C₁₈H₂₂N₃O₂S*I
• Molecular Weight: 471.362
• Mol file: 1047671-76-0.mol

Synonyms:(3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide

Chemical Property of (3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide

There total 6 articles about (3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-thiazol-4-yl)carbamate hydrochloride (1047672-88-7) + methyl iodide (74-88-4) → (3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide (1047671-76-0)

Guidance literature:

(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-thiazol-4-yl)carbamate hydrochloride; With sodium hydroxide; In water; for 0.25h;

methyl iodide; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2014.04.031

Reference yield:

C10H6N4OS → (3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide (1047671-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 1 h / 90 °C

2.1: toluene; N,N-dimethyl-formamide / 2 h / Reflux

3.1: sodium hydroxide / water / 0.25 h

3.2: 1 h / 20 °C

With sodium hydroxide; In water; N,N-dimethyl-formamide; toluene; 1.1: |Curtius Rearrangement;

DOI:10.1016/j.bmc.2014.04.031

Reference yield:

C10H6N2OS → (3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide (1047671-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene; N,N-dimethyl-formamide / 2 h / Reflux

2.1: sodium hydroxide / water / 0.25 h

2.2: 1 h / 20 °C

With sodium hydroxide; In water; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmc.2014.04.031

upstream raw materials:

(3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-thiazol-4-yl)carbamate hydrochloride

methyl iodide

ethyl-5‐phenyl‐1,3‐thiazole‐4‐carboxylate

5-phenyl-1,3-thiazole-4-carboxylic acid

Refernces