C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine

Base Information

• Chemical Name: C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine
• CAS No.: 766513-53-5
• Molecular Formula: C7H7 F3 N2
• Molecular Weight: 176.14
• Hs Code.: 2933399090
• Mol file: 766513-53-5.mol

Synonyms:1-(5-Trifluoromethylpyridin-3-yl)methanamine;[5-(Trifluoromethyl)pyridin-3-yl]methanamine

Chemical Property of C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine

Chemical Property:

• Vapor Pressure: 0.219mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 208°C at 760 mmHg
• Flash Point: 79.6°C
• PSA: 38.91000
• Density: 1.293g/cm³
• LogP: 2.25940
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

(5-(Trifluoromethyl)pyridin-3-yl)methanamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine

There total 4 articles about C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

5-(trifluoromethyl)pyridine-3-carbonitrile (951624-83-2) → [5-(trifluoromethyl)-3-pyridyl]methanamine (766513-53-5)

Guidance literature:

5-(trifluoromethyl)pyridine-3-carbonitrile; With sodium tetrahydroborate; cobalt(II) chloride; In ethanol; at 50 ℃; for 2h;

With hydrogenchloride; water; In ethanol; at 20 ℃; pH=1 - 2;

With ammonia; In ethanol; water; pH=9;

Reference yield: 30.0%

2-chloro-5-(trifluoromethyl)pyridine-3-carbonitrile (624734-22-1) → [5-(trifluoromethyl)-3-pyridyl]methanamine (766513-53-5)

Guidance literature:

With ammonia; hydrogen; nickel; In ethanol; water; for 7h; under 2068.65 Torr; Heating / reflux;

Reference yield:

2-hydroxy-5-(trifluoromethyl)nicotinonitrile → [5-(trifluoromethyl)-3-pyridyl]methanamine (766513-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: quinoline; trichlorophosphate / 2 h / 120 °C / Heating / reflux

2: ammonia; hydrogen / nickel / ethanol; water / 7 h / 2068.65 Torr / Heating / reflux

With quinoline; ammonia; hydrogen; trichlorophosphate; nickel; In ethanol; water;

upstream raw materials:

2-chloro-5-(trifluoromethyl)pyridine-3-carbonitrile

5-(trifluoromethyl)pyridine-3-carbonitrile

2-hydroxy-5-(trifluoromethyl)nicotinaldehyde

Downstream raw materials:

3,3,3-trifluoro-2-hydroxy-2-phenyl-N-{[5-(trifluoromethyl)pyridin-3-yl]methyl}propanamide

Refernces

• 1、 -. "2-HYDROXY-2-PHENYL/THIOPHENYL PROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS". Page/Page column 39. . Retrieved 2008/12/05.