4-[(N-acetyl-glycyl)-amino]-benzoic acid

Base Information

• Chemical Name: 4-[(N-acetyl-glycyl)-amino]-benzoic acid
• CAS No.: 250789-97-0
• Molecular Formula: C₁₁H₁₂N₂O₄
• Molecular Weight: 236.227
• Mol file: 250789-97-0.mol

Synonyms:4-[(N-acetyl-glycyl)-amino]-benzoic acid

Chemical Property of 4-[(N-acetyl-glycyl)-amino]-benzoic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-[(N-acetyl-glycyl)-amino]-benzoic acid

There total 2 articles about 4-[(N-acetyl-glycyl)-amino]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

acetyl chloride (75-36-5) + HCl*Gly-pABA-OH → 4-[(N-acetyl-glycyl)-amino]-benzoic acid (250789-97-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

chloroformic acid ethyl ester (541-41-3) + triethylamine (121-44-8) + N-acetylglycine (543-24-8) → 4-[(N-acetyl-glycyl)-amino]-benzoic acid (250789-97-0)

Guidance literature:

With 1,4-dioxane; Behandeln der Reaktionsloesung mit 4-Amino-benzoesaeure und wss. NaOH;

Reference yield: 38.0%

4-[(N-acetyl-glycyl)-amino]-benzoic acid (250789-97-0) + L-aspartic acid di-tert-butyl ester hydrochloride (1791-13-5,135904-71-1) → C23H33N3O7 (250789-98-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃; for 16h;

upstream raw materials:

chloroformic acid ethyl ester

triethylamine

N-acetylglycine

acetyl chloride

Downstream raw materials:

C₂₃H₃₃N₃O₇

Refernces