(S)-1-phenylethyl 2-methylpropanoate

Base Information

• Chemical Name: (S)-1-phenylethyl 2-methylpropanoate
• CAS No.: 76149-13-8
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.258
• Mol file: 76149-13-8.mol

Synonyms:(S)-1-phenylethyl 2-methylpropanoate

Chemical Property of (S)-1-phenylethyl 2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-phenylethyl 2-methylpropanoate

There total 11 articles about (S)-1-phenylethyl 2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isobutyric acid 1-phenyl-ethyl ester (7775-39-5) → (R)-1-phenylethanol (1517-69-7) + (1R)-1-phenylethyl 2-methylpropanoate (138457-64-4) + (S)-1-phenylethyl 2-methylpropanoate (76149-13-8)

Guidance literature:

With sodium carbonate; In toluene; at 40 ℃; for 72h; Solvent; Reagent/catalyst; Temperature; enantioselective reaction; Enzymatic reaction;

DOI:10.1007/s10562-020-03525-0

Reference yield:

1-Phenylethanol (98-85-1,13323-81-4) + 2-Methylpropionic anhydride (97-72-3) → (S)-1-phenylethanol (1445-91-6) + (R)-1-phenylethanol (1517-69-7) + (S)-1-phenylethyl 2-methylpropanoate (76149-13-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; at 0 ℃; for 7h; enantioselective reaction;

DOI:10.1021/acscatal.7b04001

Reference yield:

1-Phenylethanol (98-85-1,13323-81-4) + 2-Methylpropionic anhydride (97-72-3) → (S)-1-phenylethanol (1445-91-6) + (R)-1-phenylethanol (1517-69-7) + (1R)-1-phenylethyl 2-methylpropanoate (138457-64-4) + (S)-1-phenylethyl 2-methylpropanoate (76149-13-8)

Guidance literature:

With chiral 2-(3',5'-di-tert-butylphenyl)-4,4,8-trimethyl-2-phosphabicylo<3.3.0>octane; In n-heptane; for 1h; Product distribution; Ambient temperature; other catalyst; var. temp.; other carbinols;

DOI:10.1021/ja990133o

upstream raw materials:

1-Phenylethanol

2-Methylpropionic anhydride

vinyl isobutyrate

Isovaleric anhydride

Refernces

• 1、 Kinens, Artis,Balkaitis, Simonas,Ahmad, Omar K.,Piotrowski, David W.,Suna, Edgars. "Acylative Dynamic Kinetic Resolution of Secondary Alcohols: Tandem Catalysis by HyperBTM and B?ckvall's Ruthenium Complex". supporting information. p. 7189 - 7202. Retrieved 2021/05/29.
• 2、 Fujii, Kazuki,Mitsudo, Koichi,Mandai, Hiroki,Suga, Seiji. "Kinetic resolution of secondary carbinols by a chiral N,N-4-dimethylaminopyridine derivative containing a 1,1′-binaphthyl unit: Hydrogen bonding affects catalytic activity and enantioselectivity". . p. 1081 - 1092. Retrieved 2016/10/11.