benzyl 2-(benzyloxy)-N (tert-butoxycarbonyl)-5-iodo-L-phenylalanyl-O-benzyl-L-tyrosinate

Base Information

• Chemical Name: benzyl 2-(benzyloxy)-N (tert-butoxycarbonyl)-5-iodo-L-phenylalanyl-O-benzyl-L-tyrosinate
• CAS No.: 868073-45-4
• Molecular Formula: C₄₄H₄₅IN₂O₇
• Molecular Weight: 840.755
• Mol file: 868073-45-4.mol

Synonyms:benzyl 2-(benzyloxy)-N (tert-butoxycarbonyl)-5-iodo-L-phenylalanyl-O-benzyl-L-tyrosinate

Chemical Property of benzyl 2-(benzyloxy)-N (tert-butoxycarbonyl)-5-iodo-L-phenylalanyl-O-benzyl-L-tyrosinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(benzyloxy)-N (tert-butoxycarbonyl)-5-iodo-L-phenylalanyl-O-benzyl-L-tyrosinate

There total 1 articles about benzyl 2-(benzyloxy)-N (tert-butoxycarbonyl)-5-iodo-L-phenylalanyl-O-benzyl-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

H-Tyr(Bzl)-OBzl.HCl (52142-01-5) + (-)-3-(2-benzyloxy-5-iodophenyl)-2(S)-tert-butoxycarbonylaminopropionic acid (616888-56-3) → benzyl 2-(benzyloxy)-N (tert-butoxycarbonyl)-5-iodo-L-phenylalanyl-O-benzyl-L-tyrosinate (868073-45-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield: 30.0%

2-(trimethylsilyl)ethyl 2-(benzyloxy)-N-[(benzyloxy)carbonyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-L-phenylalaninate (849814-34-2) + benzyl 2-(benzyloxy)-N (tert-butoxycarbonyl)-5-iodo-L-phenylalanyl-O-benzyl-L-tyrosinate (868073-45-4) → 2-(trimethylsilyl)ethyl 2-{[(benzyloxy)carbonyl]amino}-3-(4,4'-bis(benzyloxy)-3'-{(2S)-3-({(1S)-2-(benzyloxy)-1-[4-(benzyloxy)benzyl]-2-oxoethyl}amino)-2-[(tert-butoxycarbonyl)amino]-3-oxopropyl}biphenyl-3-yl)propanoate (868073-46-5)

Guidance literature:

With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 8h;

upstream raw materials:

H-Tyr(Bzl)-OBzl_.HCl

(-)-3-(2-benzyloxy-5-iodophenyl)-2(S)-tert-butoxycarbonylaminopropionic acid

Downstream raw materials:

2-(trimethylsilyl)ethyl 2-{[(benzyloxy)carbonyl]amino}-3-(4,4'-bis(benzyloxy)-3'-{(2S)-3-({(1S)-2-(benzyloxy)-1-[4-(benzyloxy)benzyl]-2-oxoethyl}amino)-2-[(tert-butoxycarbonyl)amino]-3-oxopropyl}biphenyl-3-yl)propanoate

Refernces