METHYL 5-HEXYNOATE

Base Information

• Chemical Name: METHYL 5-HEXYNOATE
• CAS No.: 77758-51-1
• Molecular Formula: C7H10 O2
• Molecular Weight: 126.155
• Hs Code.: 29161995
• Mol file: 77758-51-1.mol

Synonyms:Methyl5-hexynoate

Chemical Property of METHYL 5-HEXYNOATE

Chemical Property:

• Refractive Index: 1.434
• Boiling Point: 60 °C
• PSA: 26.30000
• Density: 0.960±0.06 g/cm3(Predicted)
• LogP: 0.96290

Purity/Quality:

98%Min ^*data from raw suppliers

METHYL5-HEXYNOATE,95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-52
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 5-hexynoate is used in the synthesis of methyl (Z)-8-chlorooct-7-ene-5-ynoate with (Z)-1,2-dichloro-ethane.

Technology Process of METHYL 5-HEXYNOATE

There total 18 articles about METHYL 5-HEXYNOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + hex-5-ynoic acid (53293-00-8) → methyl hex-5-ynoate (77758-51-1)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 36h; Reflux;

DOI:10.1007/s10600-011-9765-z

Reference yield: 100.0%

hex-5-ynoic acid (53293-00-8) + methyl iodide (74-88-4) → methyl hex-5-ynoate (77758-51-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(96)00662-4

Reference yield: 99.0%

hex-5-ynoic acid (53293-00-8) + 2,2-dimethoxy-propane (77-76-9) → methyl hex-5-ynoate (77758-51-1)

Guidance literature:

With chloro-trimethyl-silane; In methanol; at 20 ℃; for 16h;

DOI:10.1002/ejoc.201600194

upstream raw materials:

methanol

hex-5-ynoic acid

methyl 5-hexenoate

methyl iodide

Downstream raw materials:

5-hexyl-1-ol

hex-5-ynoic acid

methyl rac-13-benzoyloxy-10-hydroxytridec-11(E)-ene-5,8-diynoate

methyl 6-(3-iodophenyl)-5-hexynoate

Refernces

• 1、 Nechaev, Ilya V.,Cherkaev, Georgij V.,Boev, Nikolay V.,Solyev, Pavel N.. "Three-Component Reaction of 3,3-Difluorocyclopropenes, s-Tetrazines, and (benzo) Pyridines". . p. 1037 - 1052. Retrieved 2021/01/09.
• 2、 Cui, Xi-Yang,Ge, Yicen,Tan, Siu Min,Jiang, Huan,Tan, Davin,Lu, Yunpeng,Lee, Richmond,Tan, Choon-Hong. "(Guanidine)copper Complex-Catalyzed Enantioselective Dynamic Kinetic Allylic Alkynylation under Biphasic Condition". supporting information. p. 8448 - 8455. Retrieved 2018/06/22.