4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid

Base Information

• Chemical Name: 4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid
• CAS No.: 93273-62-2
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.284
• Mol file: 93273-62-2.mol

Synonyms:4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid

Chemical Property of 4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid

There total 4 articles about 4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

methyl 3-hydroxy-4-<2-(methoxycarbonyl)benzyl>phenylacetate (93273-67-7) → 4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid (93273-62-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 1.5h; Heating;

DOI:10.1248/cpb.32.3047

Reference yield: 21.2%

oxepinac (55689-65-1) → 3-Methyl-6,11-dihydrodibenzoxepin-11-one (23560-72-7) + 2-methylanthracene-9,10-dione (84-54-8) + 4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid (93273-62-2) + 4-carboxy-3-(2-methylphenoxy)phenylacetic acid (93273-61-1)

Guidance literature:

With sodium hydroxide; In water; for 336h; Irradiation;

DOI:10.1248/cpb.32.3047

Reference yield:

3-(2-carboxybenzyloxy)phenylacetic acid (55690-19-2) → 4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid (93273-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95.3 percent / conc. H₂SO₄ / 22 h / Heating

2: 28.7 percent / aluminium chloride / 1,2-dichloro-ethane / 0.67 h / Ambient temperature

3: 83.5 percent / KOH / aq. ethanol / 1.5 h / Heating

With potassium hydroxide; aluminium trichloride; sulfuric acid; In ethanol; 1,2-dichloro-ethane;

DOI:10.1248/cpb.32.3047

upstream raw materials:

oxepinac

methyl 3-hydroxy-4-<2-(methoxycarbonyl)benzyl>phenylacetate

3-(2-carboxybenzyloxy)phenylacetic acid

methyl 3-<2-(methoxycarbonyl)benzyloxy>phenylacetate

Refernces