Technology Process of (4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol
There total 10 articles about (4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
dichloromethane; toluene;
at -78 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
N,N-dimethyl-formamide;
at 100 - 110 ℃;
for 6h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: cyclohexane / 2 h / Reflux; Dean-Stark
1.2: 2 h / 0 °C / Reflux; Dean-Stark
2.1: toluene-4-sulfonic acid / o-xylene / 18 h / Reflux
3.1: sodium ethanolate / ethanol / 18 h / Reflux
4.1: trichlorophosphate / 4 h / 60 °C
5.1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C / Inert atmosphere
6.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); sodium ethanolate; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; trichlorophosphate;
In
ethanol; dichloromethane; o-xylene; cyclohexane; N,N-dimethyl-formamide; toluene;
6.1: |Suzuki Coupling;