(S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal

Base Information

• Chemical Name: (S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal
• CAS No.: 111197-86-5
• Molecular Formula: C₁₄H₂₀O₃
• Molecular Weight: 236.311
• Mol file: 111197-86-5.mol

Synonyms:(S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal

Chemical Property of (S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal

There total 3 articles about (S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(S)-2-hydroxypropiophenone (5650-40-8,65646-06-2,91840-95-8,65646-07-3) + 2,2-Dimethyl-1,3-propanediol (126-30-7) → (S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal (111197-86-5)

Guidance literature:

With chloro-trimethyl-silane; In methanol; for 2h; ice bath;

DOI:10.1246/bcsj.60.1027

Reference yield:

(S)-2-(1-ethoxyethoxy)-1-phenyl-1-propanone → (S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal (111197-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / PPTS / ethanol / 6 h

2: 89 percent / trimethylchlorosilane / methanol / 2 h / ice bath

With chloro-trimethyl-silane; pyridinium p-toluenesulfonate; In methanol; ethanol;

DOI:10.1246/bcsj.60.1027

Reference yield:

(S)-2-methoxymethoxy-1-phenyl-1-propanone (111199-08-7) → (S)-2-hydroxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal (111197-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 1M HCl / methanol / 6 h / 60 °C

2: 89 percent / trimethylchlorosilane / methanol / 2 h / ice bath

With hydrogenchloride; chloro-trimethyl-silane; In methanol;

DOI:10.1246/bcsj.60.1027

upstream raw materials:

(S)-2-hydroxypropiophenone

2,2-Dimethyl-1,3-propanediol

(S)-2-methoxymethoxy-1-phenyl-1-propanone

Downstream raw materials:

3-hydroxy-2,2-dimethylpropyl (S)-2-phenylpropionate

(S)-2-methylsulfonyloxy-1-phenyl-1-propanone 2,2-dimethyl-trimethylene acetal

Refernces