Technology Process of dimethyl 3-(4-methoxyphenyl)-3,4-dihydronaphthalene-2,2(1H)-dicarboxylate
There total 6 articles about dimethyl 3-(4-methoxyphenyl)-3,4-dihydronaphthalene-2,2(1H)-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C
1.2: 0.55 h / 0 °C
1.3: 0.67 h / -78 °C
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 5 h / 50 °C / Inert atmosphere
3.1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr
4.1: tetrahydrofuran; pyridine; titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: scandium tris(trifluoromethanesulfonate) / toluene / 4.5 h / 100 °C
With
tetrahydrofuran; pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10% palladium on activated carbon; hydrogen; titanium tetrachloride; triethylamine; triphenylphosphine; scandium tris(trifluoromethanesulfonate);
In
dichloromethane; ethyl acetate; toluene;
1.1: Corey-Fuchs homologation / 1.2: Corey-Fuchs homologation / 1.3: Corey-Fuchs homologation / 2.1: Sonogashira coupling / 4.1: Knoevenagel condensation;
DOI:10.1016/j.tetlet.2009.06.007
- Guidance literature:
-
Multi-step reaction with 5 steps
1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 5 h / 50 °C / Inert atmosphere
3: 10% palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr
4: tetrahydrofuran; pyridine; titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere
5: scandium tris(trifluoromethanesulfonate) / toluene / 4.5 h / 100 °C
With
tetrahydrofuran; pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; 10% palladium on activated carbon; hydrogen; titanium tetrachloride; triethylamine; scandium tris(trifluoromethanesulfonate);
In
tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
2: Sonogashira coupling / 4: Knoevenagel condensation;
DOI:10.1016/j.tetlet.2009.06.007