5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol

Base Information

• Chemical Name: 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol
• CAS No.: 182629-25-0
• Molecular Formula: C₁₄H₂₄O₃Si
• Molecular Weight: 268.428
• Mol file: 182629-25-0.mol

Synonyms:5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol

Chemical Property of 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol

There total 8 articles about 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dimethyl 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dicarboxylate (182629-24-9) → 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol (182629-25-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 5h;

DOI:10.1002/1522-2675(200201)85:1<288::AID-HLCA288>3.0.CO;2-I

Reference yield:

Dimethyl 5-hydroxyisophthalate (13036-02-7) → 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol (182629-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / 1H-imidazole / dimethylformamide / 3 h / 0 °C

2: 97 percent / LiAlH₄ / tetrahydrofuran / 5 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(200201)85:1<288::AID-HLCA288>3.0.CO;2-I

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol (182629-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

2: 93 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/a608577f

upstream raw materials:

5-(tert-butyldimethylsilyloxy)isophthalic acid

dimethyl 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dicarboxylate

Dimethyl 5-hydroxyisophthalate

tert-butyldimethylsilyl chloride

Downstream raw materials:

1-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-3,5-bis{{[(1,1-dimethylethyl)dimethylsilyl]oxy}methyl}benzene

5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}benzene-1,3-dimethanol diacetate

1-(tert-butyl-(dimethyl)-silyloxy)-3,5-bis-triisopropylsilyloxymethyl benzene

methyl 3-acetyl-5-hydroxybenzoate

Refernces

• 1、 Jimenez, M. Belen,Fuentes De Arriba, Angel L.,Calle, Emilio,Caballero, M. Cruz. "Fluorescent receptor for dicarboxylates based on pyrrolecarboxamides". experimental part. p. 361 - 368. Retrieved 2012/10/07.
• 2、 Felder, Delphine,Nava, Manuel Gutierrez,Del Pilar Carreon, Maria,Eckert, Jean-Francois,Luccisano, Michael,Schall, Corinne,Masson, Patrick,Gallani, Jean-Louis,Heinrich, Benoit,Guillon, Daniel,Nierengarten, Jean-Francois. "Synthesis of amphiphilic fullerene derivatives and their incorporation in Langmuir and Langmuir-Blodgett films". . p. 288 - 319. Retrieved 2007/10/03.