4-(2-aminophenyl)-2-butanol

Base Information

• Chemical Name: 4-(2-aminophenyl)-2-butanol
• CAS No.: 457622-20-7
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.235
• Mol file: 457622-20-7.mol

Synonyms:4-(2-aminophenyl)-2-butanol

Chemical Property of 4-(2-aminophenyl)-2-butanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-aminophenyl)-2-butanol

There total 1 articles about 4-(2-aminophenyl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

N-(tert-butoxycarbonyl)-o-toluidine (74965-31-4) + methyloxirane (75-56-9,16033-71-9) → 4-(2-aminophenyl)-2-butanol (457622-20-7)

Guidance literature:

N-(tert-butoxycarbonyl)-o-toluidine; methyloxirane; With n-butyllithium; In tetrahydrofuran; hexane; at -70 - 0 ℃; for 13h;

With hydrogenchloride; In methanol; water; at 20 ℃; for 29h; Further stages.;

DOI:10.1021/ol026200s

Reference yield: 83.0%

4-(2-aminophenyl)-2-butanol (457622-20-7) → 2-methylquinoline (91-63-4) + 1,2,3,4-tetrahydro-2-methylquinoline (1780-19-4)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium carbonate; In toluene; at 111 ℃; for 20h;

DOI:10.1021/ol026200s

Reference yield: 52.0%

p-toluenesulfonyl chloride (98-59-9) + 4-(2-aminophenyl)-2-butanol (457622-20-7) → C17H21NO3S (953395-33-0)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ol701737x

upstream raw materials:

N-(tert-butoxycarbonyl)-o-toluidine

methyloxirane

Downstream raw materials:

2-methylquinoline

1,2,3,4-tetrahydro-2-methylquinoline

C₁₇H₂₁NO₃S

(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 4-pentynoate

Refernces