5-BROMO-7-METHYL-1H-INDOLE-2,3-DIONE

Base Information

• Chemical Name: 5-BROMO-7-METHYL-1H-INDOLE-2,3-DIONE
• CAS No.: 77395-10-9
• Molecular Formula: C9H6BrNO2
• Molecular Weight: 240.056
• Hs Code.: 2933990090
• Mol file: 77395-10-9.mol

Synonyms:Isatin,5-bromo-7-methyl- (2CI);

Chemical Property of 5-BROMO-7-METHYL-1H-INDOLE-2,3-DIONE

Chemical Property:

• Melting Point: 262℃ (decomposition)
• PSA: 46.17000
• Density: 1.714 g/cm³
• LogP: 2.03030
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

5-Bromo-7-methyl-1H-indole-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-7-methyl-1H-indole-2,3-dione can be used as an anti-inflammatory agent. It can also be used to modulate CFTR activity and AMPA receptor modules.

Technology Process of 5-BROMO-7-METHYL-1H-INDOLE-2,3-DIONE

There total 9 articles about 5-BROMO-7-METHYL-1H-INDOLE-2,3-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(4-bromo-2-methylphenyl)-2-(N-hydroxyimino)acetamide → 5-bromo-7-methyl-2,3-d1H ydro-1H-indole-2,3-dione (77395-10-9)

Guidance literature:

With sulfuric acid; at 80 ℃; for 2h;

Reference yield: 88.0%

7-methyl-1H-indole-2,3-dione (1127-59-9) → 5-bromo-7-methyl-2,3-d1H ydro-1H-indole-2,3-dione (77395-10-9)

Guidance literature:

With bromine; In chloroform; for 24h; Heating;

DOI:10.1021/jo060553d

Reference yield: 31.0%

3-methyl-2-nitro-1-[2-(trimethylsilyl)ethynyl]-benzene (1189051-96-4) → 5-bromo-7-methyl-2,3-d1H ydro-1H-indole-2,3-dione (77395-10-9)

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In N,N-dimethyl-formamide; at 20 ℃; for 45h; Inert atmosphere; Darkness;

DOI:10.1016/j.tet.2009.06.098

upstream raw materials:

7-methyl-1H-indole-2,3-dione

o-toluidine

4-Bromo-2-methylaniline

3-methyl-2-nitro-1-[2-(trimethylsilyl)ethynyl]-benzene

Downstream raw materials:

7-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

2,5-dibromo-3-methylbenzoic acid

2,5-dibromo-3-methyl benzoic acid methyl ester

Refernces

• 1、 -. "COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR". . . Retrieved 2017/08/01.
• 2、 S?derberg, Bj?rn C.G.,Gorugantula, Sobha P.,Howerton, Chet R.,Petersen, Jeffrey L.,Dantale, Shubhada W.. "A palladium-catalyzed synthesis of isatins (1H-Indole-2,3-diones) from 1-(2-haloethynyl)-2-nitrobenzenes". experimental part. p. 7357 - 7363. Retrieved 2009/12/04.