N,N-dibenzyl-(R)-2-amino-3-phenylpropanal

Base Information

• Chemical Name: N,N-dibenzyl-(R)-2-amino-3-phenylpropanal
• CAS No.: 123054-12-6
• Molecular Formula: C₂₃H₂₃NO
• Molecular Weight: 329.442
• Mol file: 123054-12-6.mol

Synonyms:N,N-dibenzyl-(R)-2-amino-3-phenylpropanal

Chemical Property of N,N-dibenzyl-(R)-2-amino-3-phenylpropanal

Chemical Property:

• Boiling Point: 446.0±45.0 °C(Predicted)
• Density: 1.105±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-dibenzyl-(R)-2-amino-3-phenylpropanal

There total 26 articles about N,N-dibenzyl-(R)-2-amino-3-phenylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-(dibenzylamino)-3-phenylpropan-1-ol (111060-52-7) → (2S)-N,N-dibenzylphenylalaninal (123054-12-6,123808-74-2,136370-73-5,111060-64-1)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃;

DOI:10.1080/00397911.2011.572217

Reference yield: 99.9%

βS-2-[bis(phenylmethyl)amino]benzenepropanol → (2S)-N,N-dibenzylphenylalaninal (123054-12-6,123808-74-2,136370-73-5,111060-64-1)

Guidance literature:

With sulfur trioxide; In water; dimethyl sulfoxide; triethylamine;

Reference yield: 99.9%

2S-[bis(phenylmethyl)amino]-3-phenylpropanol → (2S)-N,N-dibenzylphenylalaninal (123054-12-6,123808-74-2,136370-73-5,111060-64-1)

Guidance literature:

With sulfur trioxide; In water; dimethyl sulfoxide; triethylamine;

upstream raw materials:

(S)-2-(dibenzylamino)-3-phenylpropan-1-ol

methyl (2S)-2-amino-3-phenylpropanoate

benzyl bromide

N,N-dibenzyl-L-phenylalanine benzyl ester

Downstream raw materials:

(1S,2S)-2-Dibenzylamino-3-phenyl-1-pyridin-2-yl-propan-1-ol

(1R,2S)-2-Dibenzylamino-3-phenyl-1-pyridin-2-yl-propan-1-ol

(2S,3S)-3-(dibenzylamino)-4-phenylbutan-2-ol

(2R,3S)-3-(dibenzylamino)-4-phenylbutan-2-ol

Refernces

• 1、 Neouchy, Zeina,Gomez Pardo, Domingo,Cossy, Janine. "Synthesis of Optically Active α-Trifluoromethylamines by Rearrangement of β-Amino-α-trifluoromethyl Alcohols". supporting information. p. 6017 - 6021. Retrieved 2018/09/25.
• 2、 Ka?mierczak, Marcin,Kubicki, Maciej,Koroniak, Henryk. "A - And B -fluorinated aminophosphonates-Synthesis and properties". . p. 459 - 468. Retrieved 2016/04/09.