2-Amino-2-methylbutanoic acid hydrochloride

Base Information

• Chemical Name: 2-Amino-2-methylbutanoic acid hydrochloride
• CAS No.: 72408-58-3
• Molecular Formula: C5H11 N O2 . Cl H
• Molecular Weight: 153.609
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID10870655
• Mol file: 72408-58-3.mol

Synonyms:2-amino-2-methylbutanoic acid hydrochloride;72408-58-3;2-AMINO-2-METHYL-BUTYRIC ACID HYDROCHLORIDE;2-amino-2-methylbutanoic acid;hydrochloride;ISOVALINE HYDROCHLORIDE;2-Amino-2-methylbutyric hydrochloride;Isovaline hydrochloride (1:1);SCHEMBL1236580;DTXSID10870655;CYBOBNODYVJFNM-UHFFFAOYSA-N;MFCD07368321;AKOS030231511;2-amino-2-methylbutanoic acid HCl salt;2-amino-2-methylbutanoicacidhydrochloride;2-Amino-2-methylbutyric acid hydrochloride;DB-120481;CS-0245856;2-azanyl-2-methyl-butanoic acid hydrochloride;EN300-312512;G29955;A832357

Chemical Property of 2-Amino-2-methylbutanoic acid hydrochloride

Chemical Property:

• Melting Point: 246 °C(Solv: isopropanol (67-63-0))
• PSA: 63.32000
• LogP: 1.70070
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 153.0556563
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)(C(=O)O)N.Cl

Technology Process of 2-Amino-2-methylbutanoic acid hydrochloride

There total 1 articles about 2-Amino-2-methylbutanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-2-methylbutanenitrile (4475-95-0) → 2-amino-2-methylbutyric acid hydrochloride (72408-58-3)

Guidance literature:

With hydrogenchloride; water; for 2h; Reflux;

DOI:10.1021/jo802058x

Reference yield: 99.0%

benzyl chloroformate (501-53-1,94274-21-2) + 2-amino-2-methylbutyric acid hydrochloride (72408-58-3) → 2-(((benzyloxy)carbonyl)amino)-2-methylbutanoic acid (4512-49-6)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 23 ℃; for 24h;

Reference yield: 84.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 2-amino-2-methylbutyric acid hydrochloride (72408-58-3) → 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid (160885-93-8)

Guidance literature:

2-amino-2-methylbutyric acid hydrochloride; With water; sodium carbonate;

(fluorenylmethoxy)carbonyl chloride; In 1,4-dioxane;

With hydrogenchloride; water;

DOI:10.1021/jo802058x

upstream raw materials:

2-amino-2-methylbutanenitrile

Downstream raw materials:

2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-methylbutanoic acid

2-(((benzyloxy)carbonyl)amino)-2-methylbutanoic acid

Refernces