5-(4-tert-butylphenyl)-2-n-propylthiazole

Base Information

• Chemical Name: 5-(4-tert-butylphenyl)-2-n-propylthiazole
• CAS No.: 1005759-21-6
• Molecular Formula: C₁₆H₂₁NS
• Molecular Weight: 259.415
• Mol file: 1005759-21-6.mol

Synonyms:5-(4-tert-butylphenyl)-2-n-propylthiazole

Chemical Property of 5-(4-tert-butylphenyl)-2-n-propylthiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-tert-butylphenyl)-2-n-propylthiazole

There total 2 articles about 5-(4-tert-butylphenyl)-2-n-propylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-(n-propyl)-thiazole (17626-75-4) + 1-bromo-4-tert-butylbenzene (3972-65-4) → 5-(4-tert-butylphenyl)-2-n-propylthiazole (1005759-21-6)

Guidance literature:

With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 150 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jo802360d

Reference yield: 58.0%

2-(n-propyl)-thiazole (17626-75-4) + 4-tert-butylphenyl triflate (154318-75-9) → 5-(4-tert-butylphenyl)-2-n-propylthiazole (1005759-21-6)

Guidance literature:

With potassium acetate; triphenylphosphine; palladium diacetate; In N,N-dimethyl-formamide; at 150 ℃; for 20h;

DOI:10.1039/b715235c

upstream raw materials:

2-(n-propyl)-thiazole

4-tert-butylphenyl triflate

1-bromo-4-tert-butylbenzene

Refernces

• 1、 Roger, Julien,Pozgan, Franc,Doucet, Henri. "Ligand-free palladium-catalyzed direct arylation of thiazoles at low catalyst loadings". supporting information; experimental part. p. 1179 - 1186. Retrieved 2009/08/08.