7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate

Base Information

• Chemical Name: 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate
• CAS No.: 74420-18-1
• Molecular Formula: C₇H₄ClO₂*C₇H₇N₂O
• Molecular Weight: 290.706
• Mol file: 74420-18-1.mol

Synonyms:7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate

Chemical Property of 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate

There total 1 articles about 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-Azaindole (271-63-6) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate (74420-18-1)

Guidance literature:

In Dimethyl ether; n-heptane; at 20 ℃; for 2.5h;

DOI:10.5012/bkcs.2012.33.5.1571

Reference yield: 80.0%

7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate (74420-18-1) → 4-chloro-7-azaindole (55052-28-3)

Guidance literature:

With trichlorophosphate; at 20 - 90 ℃; for 18h;

DOI:10.5012/bkcs.2012.33.5.1571

Reference yield:

7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate (74420-18-1) → 4-chloro-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one (346599-62-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / water / pH 11

2: N,N-dimethyl-formamide / 50 - 72 °C

3: pyridinium hydrobromide perbromide / tert-butyl alcohol / 20 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 6.25 h / 20 °C

With pyridinium hydrobromide perbromide; hydrogen; potassium carbonate; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

7-Azaindole

3-chloro-benzenecarboperoxoic acid

Downstream raw materials:

3-nitro-1H-pyrrolo<2,3-b>pyridine 7-oxide

1H-Pyrrolo[2,3-b]pyridine-7-oxide

4-chloro-7-azaindole

N-(1-(4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide

Refernces

• 1、 El-Gamal, Mohammed I.,Oh, Chang-Hyun. "Pyrrolo[3,2-c]pyridine derivatives with potential inhibitory effect against FMS kinase: in vitro biological studies". . p. 1160 - 1166. Retrieved 2018/08/12.
• 2、 Cincinelli, Raffaella,Musso, Loana,Merlini, Lucio,Giannini, Giuseppe,Vesci, Loredana,Milazzo, Ferdinando M.,Carenini, Nives,Perego, Paola,Penco, Sergio,Artali, Roberto,Zunino, Franco,Pisano, Claudio,Dallavalle, Sabrina. "7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors". . p. 1089 - 1103. Retrieved 2014/02/14.