n-butyl-4-amino-4-deoxy-5-deazapteroate

Base Information

• Chemical Name: n-butyl-4-amino-4-deoxy-5-deazapteroate
• CAS No.: 141397-60-6
• Molecular Formula: C₁₉H₂₂N₆O₂
• Molecular Weight: 366.423
• Mol file: 141397-60-6.mol

Synonyms:n-butyl-4-amino-4-deoxy-5-deazapteroate

Chemical Property of n-butyl-4-amino-4-deoxy-5-deazapteroate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of n-butyl-4-amino-4-deoxy-5-deazapteroate

There total 1 articles about n-butyl-4-amino-4-deoxy-5-deazapteroate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-benzoic acid butyl ester (94-25-7) + 2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine (80360-04-9) → n-butyl-4-amino-4-deoxy-5-deazapteroate (141397-60-6)

Guidance literature:

With 3 A molecular sieve; N-tert-butylaminoborane; acetic acid; Yield given. Multistep reaction;

DOI:10.1021/jm00089a009

Reference yield: 86.0%

n-butyl-4-amino-4-deoxy-5-deazapteroate (141397-60-6) → 5-deazapteroic acid (141397-61-7)

Guidance literature:

With sodium hydroxide; for 8h; Heating;

DOI:10.1021/jm00089a009

Reference yield:

n-butyl-4-amino-4-deoxy-5-deazapteroate (141397-60-6) → Nα-(5,6,7,8-tetrahydro-5-deazapteroyl)-L-ornithine (141397-59-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 86 percent / 0.5 N NaOH / 8 h / Heating

2: 79 percent / Ac₂O / 3 h / Ambient temperature

3: 76 percent / H₂, CF₃COOH / PtO₂ / 3 h / 25 °C / 2327.2 - 2844.3 Torr

4: 58 percent / 1N NaOH / 15 h / 45 °C

5: 2.) Et₃N, i-BuOCOCl / 1.) 72 h, 2.) a. 0 deg C, 5 h, b. RT, 18 h

6: 58 percent / CF₃COOH / 2 h / Ambient temperature

With sodium hydroxide; hydrogen; acetic anhydride; triethylamine; trifluoroacetic acid; isobutyl chloroformate; platinum(IV) oxide;

DOI:10.1021/jm00089a009

upstream raw materials:

4-amino-benzoic acid butyl ester

2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine

Downstream raw materials:

5-deazapteroic acid

N^α-(5,6,7,8-tetrahydro-5-deazapteroyl)-L-ornithine

5-deaza-5,6,7,8-tetrahydropteroic acid

10-formyl-5-deazapteroic acid

Refernces