1-(2,6-Dichloro-3-fluorophenyl)ethanol

Base Information

• Chemical Name: 1-(2,6-Dichloro-3-fluorophenyl)ethanol
• CAS No.: 756520-66-8
• Molecular Formula: C8H7Cl2FO
• Molecular Weight: 209.047
• Hs Code.: 2906299090
• Mol file: 756520-66-8.mol

Synonyms:Benzenemethanol, 2,6-dichloro-3-fluoro-α-methyl-;1-(2,6-Dichloro-3-fluorophenyl)ethan-1-ol;2,6-Dichloro-3-fluoro-α-methylbenzenemethanol;

Chemical Property of 1-(2,6-Dichloro-3-fluorophenyl)ethanol

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.547
• Boiling Point: 261.329 °C at 760 mmHg
• PKA: 13.30±0.20(Predicted)
• Flash Point: 111.848 °C
• PSA: 20.23000
• Density: 1.407 g/cm³
• LogP: 3.18580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2,6-Dichloro-3-fluorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,6-Dichloro-3-fluorophenyl)ethanol

There total 5 articles about 1-(2,6-Dichloro-3-fluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2',6'-dichloro-3'-fluoroacetophenone (290835-85-7) → 1-(2,6-dichloro-3-fluorophenyl)ethanol (756520-66-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 0.666667h;

Reference yield: 46.16%

2,6-dichloro-3-fluorobenzaldehyde (178813-77-9) → 1-(2,6-dichloro-3-fluorophenyl)ethanol (756520-66-8)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

2,6-dichloro-3-fluoroacetophenone → 1-(2,6-dichloro-3-fluorophenyl)ethanol (756520-66-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 12h; Reagent/catalyst; Solvent;

upstream raw materials:

2',6'-dichloro-3'-fluoroacetophenone

D-glucose

1,3-dichloro-4-fluorobenzene

2,6-dichloro-3-fluorobenzaldehyde

Downstream raw materials:

3-[(2,6-dichloro-3-fluorophenyl)methoxy]-2-nitropyridine

6-chloro-4-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazin-3-ylamine

C₁₄H₁₁Cl₂FN₂O₃

5-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

Refernces

• 1、 Forsyth, Sian M.,Moseley, Jonathan D.,Raynbird, Marina Y.,Sampson, Joanne B.,Smith, Dan A.,Wells, Andrew S.. "Ketone Reductase Biocatalysis in the Synthesis of Chiral Intermediates Toward Generic Active Pharmaceutical Ingredients". supporting information. . Retrieved 2020/06/29.
• 2、 -. "A (S)-1 - (2, 6 - dichloro -3 - fluoro phenyl) ethanol preparation method". Paragraph 0024; 0025. . Retrieved 2019/04/02.