(4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE

Base Information

• Chemical Name: (4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE
• CAS No.: 72141-41-4
• Molecular Formula: C11H13 N3 O3
• Molecular Weight: 235.243
• Hs Code.: 2933599090
• Mol file: 72141-41-4.mol

Synonyms:Piperazine,1-(4-nitrobenzoyl)- (9CI); 1-(4-Nitrobenzoyl)piperazine;1-(p-Nitrobenzoyl)piperazine

Chemical Property of (4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE

Chemical Property:

• Vapor Pressure: 4.48E-08mmHg at 25°C
• Melting Point: 158-161°C
• Refractive Index: 1.589
• Boiling Point: 443.9°C at 760 mmHg
• PKA: 8.24±0.10(Predicted)
• Flash Point: 222.2°C
• PSA: 78.16000
• Density: 1.289g/cm³
• LogP: 1.43010
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Nitrobenzoyl)piperazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE

There total 18 articles about (4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

piperazine (110-85-0) + 4-nitro-benzoic acid (62-23-7) → (4-nitro-phenyl)-piperazin-1-yl-methanone (72141-41-4)

Guidance literature:

4-nitro-benzoic acid; With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 - 5 ℃; for 0.25h;

piperazine; With pyridine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1081/SCC-200026630

Reference yield: 93.0%

piperazine (110-85-0) + p-nitrobenzene iodide (636-98-6) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → (4-nitro-phenyl)-piperazin-1-yl-methanone (72141-41-4)

Guidance literature:

In N,N-dimethyl-formamide; at 25 ℃; for 48h; Irradiation; Green chemistry;

DOI:10.1039/d0cy01717e

Reference yield: 84.0%

N-(4-nitrobenzoyl)imidazole (10364-96-2) + piperazine dihydrochloride (142-64-3,8006-71-1) → (4-nitro-phenyl)-piperazin-1-yl-methanone (72141-41-4)

Guidance literature:

In ethanol; water; at 20 ℃; for 6.16667h;

DOI:10.1021/ol101604q

upstream raw materials:

piperazine

2,4-dinitrophenyl p-nitrobenzoate

4-nitro-benzoyl chloride

4-nitrophenyl 4-nitrobenzoate

Downstream raw materials:

C₂₅H₂₁N₅O₅S

C₁₄H₁₉N₃O₃

Refernces

• 1、 Mancuso, Francesca,Di Fiore, Anna,De Luca, Laura,Angeli, Andrea,Monti, Simona M.,De Simone, Giuseppina,Supuran, Claudiu T.,Gitto, Rosaria. "Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms". . p. 1000 - 1005. Retrieved 2020/03/23.
• 2、 Wodtke, Robert,Hauser, Christoph,Ruiz-Gómez, Gloria,J?ckel, Elisabeth,Bauer, David,Lohse, Martin,Wong, Alan,Pufe, Johanna,Ludwig, Friedrich-Alexander,Fischer, Steffen,Hauser, Sandra,Greif, Dieter,Pisabarro, M. Teresa,Pietzsch, Jens,Pietsch, Markus,L?ser, Reik. "N?-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure-Activity Relationships, and Pharmacokinetic Profiling". . p. 4528 - 4560. Retrieved 2018/05/07.