5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE

Base Information

• Chemical Name: 5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE
• CAS No.: 756437-41-9
• Molecular Formula: C7H9 N3 O
• Molecular Weight: 151.168
• Mol file: 756437-41-9.mol

Synonyms:Pyrido[4,3-d]pyrimidin-4(1H)-one,5,6,7,8-tetrahydro- (9CI); 5,6,7,8-Tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one

Chemical Property of 5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE

Chemical Property:

• PSA: 57.78000
• LogP: -0.25560
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE

There total 2 articles about 5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.6%

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (109229-22-3) → 5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one (756437-41-9)

Guidance literature:

With formic acid; triethylamine; palladium dihydroxide; In methanol; at 60 - 65 ℃; for 3.25h;

Reference yield:

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one (756437-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium alcoholate / ethanol / 2 h / Reflux

2: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C

With formic acid; triethylamine; palladium(II) hydroxide; In methanol; ethanol;

Reference yield:

5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one (756437-41-9) + 4-biphenyl-carboxylic acid chloride (14002-51-8) → C20H17N3O2 (1332455-31-8)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 25 ℃; for 3.25h;

upstream raw materials:

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

Downstream raw materials:

C₂₀H₁₇N₃O₂

1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-4-yl]piperidin-4-yl}propan-1-one

1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone

Refernces

• 1、 -. "TASK CHANNEL ANTAGONISTS". Page/Page column 39. . Retrieved 2011/09/30.
• 2、 -. "Fused heterocyclic compounds, and compositions and uses thereof". Page/Page column 23; 27; 38. . Retrieved 2008/06/13.