C₂₂H₃₈O₄

Base Information

• Chemical Name: C₂₂H₃₈O₄
• CAS No.: 1289377-52-1
• Molecular Formula: C₂₂H₃₈O₄
• Molecular Weight: 366.541
• Mol file: 1289377-52-1.mol

Synonyms:C₂₂H₃₈O₄

Chemical Property of C₂₂H₃₈O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₃₈O₄

There total 9 articles about C₂₂H₃₈O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C22H36O4 (1289377-51-0) → C22H38O4 (1289377-52-1)

Guidance literature:

C₂₂H₃₆O₄; With sodium tetrahydroborate; acetic acid; In acetonitrile; at 20 - 25 ℃; for 4h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 20 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol2007567

Reference yield:

C15H22O2 (1289377-46-3) → C22H38O4 (1289377-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 20 - 25 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - -50 °C / Inert atmosphere

2.2: 3.17 h / -78 °C / Inert atmosphere

3.1: sodium tetrahydroborate; acetic acid / acetonitrile / 4 h / 20 - 25 °C / Inert atmosphere

3.2: 2 h / 20 - 25 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ol2007567

Reference yield:

(3S,4R)-1-Benzyloxy-4-methyl-hex-5-en-3-ol (909803-71-0) → C22H38O4 (1289377-52-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 25 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 20 - 25 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - -50 °C / Inert atmosphere

3.2: 3.17 h / -78 °C / Inert atmosphere

4.1: sodium tetrahydroborate; acetic acid / acetonitrile / 4 h / 20 - 25 °C / Inert atmosphere

4.2: 2 h / 20 - 25 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium hydride; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ol2007567

upstream raw materials:

(3S,4R)-1-Benzyloxy-4-methyl-hex-5-en-3-ol

(4R)-4-benzyl-3-[(2R)-2-methylpentanoyl]-1,3-oxazolidin-2-one

C₁₅H₂₂O₂

C₈H₁₇NO₂

Downstream raw materials:

C₃₄H₆₆O₄Si₂

C₂₅H₄₂O₄

Refernces