C₄₈H₄₉N₅O₁₀

Base Information

• Chemical Name: C₄₈H₄₉N₅O₁₀
• CAS No.: 1400443-20-0
• Molecular Formula: C₄₈H₄₉N₅O₁₀
• Molecular Weight: 855.945
• Mol file: 1400443-20-0.mol

Synonyms:C₄₈H₄₉N₅O₁₀

Chemical Property of C₄₈H₄₉N₅O₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₄₉N₅O₁₀

There total 4 articles about C₄₈H₄₉N₅O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C49H51N5O10 (1400443-14-2) → C48H49N5O10 (1400443-20-0)

Guidance literature:

C₄₉H₅₁N₅O₁₀; With sodium hydroxide; In methanol; at 0 - 20 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In methanol; water; pH=3; Inert atmosphere;

DOI:10.1021/jm300947s

Reference yield:

methyl (tert-butoxycarbonyl)-L-phenylalanyl-L-phenylalaninate (15215-74-4) → C48H49N5O10 (1400443-20-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: sodium hydroxide / methanol / 3 h / 0 - 20 °C / Inert atmosphere

5.2: pH 3 / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm300947s

Reference yield:

C32H36N4O6*C2HF3O2 (1400443-09-5) → C48H49N5O10 (1400443-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 3 h / 0 - 20 °C / Inert atmosphere

2.2: pH 3 / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm300947s

upstream raw materials:

methyl (tert-butoxycarbonyl)-L-phenylalanyl-L-phenylalaninate

N-tert-butoxycarbonyl-L-phenylalanine

C₃₂H₃₆N₄O₆*C₂HF₃O₂

C₄₉H₅₁N₅O₁₀

Downstream raw materials:

C₄₈H₅₀N₆O₉

Refernces