Technology Process of tert-butyl 10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane-3-carboxylate
There total 6 articles about tert-butyl 10-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-8-oxa-3,10-diazabicyclo[4.3.1]decane-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
at 50 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: caesium carbonate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation
2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 50 °C
With
benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
2: triethylamine / dichloromethane / 48 h / 20 °C
3: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 2 h
4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 50 °C
With
lithium aluminium tetrahydride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
20% palladium hydroxide-activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;