[2-(4-bromophenyl)ethynyl]diphenylphosphine oxide

Base Information

• Chemical Name: [2-(4-bromophenyl)ethynyl]diphenylphosphine oxide
• CAS No.: 1351165-66-6
• Molecular Formula: C₂₀H₁₄BrOP
• Molecular Weight: 381.208
• Mol file: 1351165-66-6.mol

Synonyms:[2-(4-bromophenyl)ethynyl]diphenylphosphine oxide

Chemical Property of [2-(4-bromophenyl)ethynyl]diphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [2-(4-bromophenyl)ethynyl]diphenylphosphine oxide

There total 10 articles about [2-(4-bromophenyl)ethynyl]diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,4-bromoiodobenzene (589-87-7) + ethynyl(diphenyl)phosphine oxide (6104-48-9) → [2-(4-bromophenyl)ethynyl]diphenylphosphine oxide (1351165-66-6)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; In toluene; at 80 ℃; for 15h; Inert atmosphere;

DOI:10.1021/jo402176w

Reference yield: 81.0%

4-bromo-1-ethynylbenzene (766-96-1) + Diphenylphosphine oxide (4559-70-0) → [2-(4-bromophenyl)ethynyl]diphenylphosphine oxide (1351165-66-6)

Guidance literature:

With silver tetrafluoroborate; palladium diacetate; triethylamine; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4cc09567g

Reference yield: 79.0%

(2-oxo-2-(4-bromophenyl)ethyl)diphenylphosphine oxide (19797-85-4) → [2-(4-bromophenyl)ethynyl]diphenylphosphine oxide (1351165-66-6)

Guidance literature:

(2-oxo-2-(4-bromophenyl)ethyl)diphenylphosphine oxide; With lithium hexamethyldisilazane; In tetrahydrofuran; Inert atmosphere;

With diethyl chlorophosphate; In tetrahydrofuran; for 1h; Inert atmosphere;

With lithium hexamethyldisilazane; In tetrahydrofuran; for 1h; Inert atmosphere;

DOI:10.1080/00397911.2016.1198812

upstream raw materials:

1,4-bromoiodobenzene

ethynyl(diphenyl)phosphine oxide

trimethylsilyl(diphenylphosphanyl)acetylene

ethynyldiphenylphosphine

Refernces

• 1、 Guo, Jiami,Mao, Chenlu,Deng, Bin,Ye, Liyi,Yin, Yingwu,Gao, Yuxing,Tu, Song. "Azobisisobutyronitrile-Initiated Oxidative C-H Functionalization of Simple Alcohols with Diaryl(arylethynyl)phosphine Oxides: A Metal-Free Approach toward Hydroxymethyl Benzo[ b]phosphole Oxides and 6 H-Indeno[2,1- b]phosphindole 5-Oxide Derivatives". . p. 6359 - 6371. Retrieved 2020/07/14.
• 2、 Chen, Hong,Zheng, Qingjuan,Dong, Wanrong,Peng, Zhihong,An, Delie. "Preparations of N- and P-substituted acetylenes under metal-free conditions". supporting information. p. 1438 - 1445. Retrieved 2016/09/14.