Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-
There total 5 articles about 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphate buffer; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
pH=7;
- Guidance literature:
-
5-bromo-1H-pyrrolo[2,3-b]pyridine;
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 0 ℃;
for 0.166667h;
tert-butyldimethylsilyl chloride;
In
DMF (N,N-dimethyl-formamide);
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; formic acid / palladium 10% on activated carbon / 120 h / 0 - 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 3 h / 0 °C
3.1: bromine; pyridine / dichloromethane / 2 h / 0 °C
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h
With
pyridine; formic acid; bromine; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
palladium 10% on activated carbon;
In
dichloromethane; N,N-dimethyl-formamide; mineral oil;