2,3,4,5-Tetramethoxybenzoic acid

Base Information

• Chemical Name: 2,3,4,5-Tetramethoxybenzoic acid
• CAS No.: 72023-44-0
• Molecular Formula: C11H14 O6
• Molecular Weight: 242.229
• Mol file: 72023-44-0.mol

Synonyms:2,3,4,5-Tetramethoxybenzoicacid

Chemical Property of 2,3,4,5-Tetramethoxybenzoic acid

Chemical Property:

• PSA: 74.22000
• LogP: 1.41920

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,5-Tetramethoxybenzoic acid

There total 18 articles about 2,3,4,5-Tetramethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,3,4,5-tetramethoxybenzaldehyde (65884-12-0) → 2,3,4,5-tetramethoxybenzoic acid (72023-44-0)

Guidance literature:

With urea hydrogen peroxide adduct; sodium hydroxide; In methanol; water; for 1.5h; Reflux;

DOI:10.1016/j.bmcl.2011.01.124

Reference yield: 90.0%

2-bromo-3,4,5-trimethoxybenzoic acid (23346-82-9) + sodium methylate (124-41-4) → 2,3,4,5-tetramethoxybenzoic acid (72023-44-0)

Guidance literature:

With copper; In methanol; for 18h; Heating;

DOI:10.1021/ja00252a022

Reference yield:

Eudesmic acid (118-41-2) → 2,3,4,5-tetramethoxybenzoic acid (72023-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Br₂ / H₂O; CHCl₃ / 18 h / Heating

2: 90 percent / Cu powder / methanol / 18 h / Heating

With bromine; copper; In methanol; chloroform; water;

DOI:10.1021/ja00252a022

upstream raw materials:

diazomethane

3,4-dihydroxy-2,5-dimethoxy-benzoic acid

2-bromo-3,4,5-trimethoxybenzoic acid

sodium methylate

Downstream raw materials:

N-methoxy-N-methyl-2,3,4,5-tetramethoxybenzamide

C₂₄H₃₄O₇Si

(3-hydroxy-4-methoxyphenyl)(2,3,4,5-tetramethoxyphenyl)methanone

4'-decyl-2-methoxy-2'-(2'',3'',4'',5''-tetramethoxybenzoyloxy)acetophenone

Refernces

• 1、 Caldwell, Stuart T.,McPhail, Donald B.,Duthie, Garry G.,Hartley, Richard C.. "Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants". scheme or table. p. 23 - 33. Retrieved 2012/03/07.
• 2、 Quijano, L.,Calderon, J. S.,Gomez, F.,Rios, T.. "TWO POLYMETHOXYFLAVONES FROM AGERATUM HOUSTONIANUM". . p. 2965 - 2968. Retrieved 2007/10/02.