C₅₀H₇₄O₁₆S

Base Information

• Chemical Name: C₅₀H₇₄O₁₆S
• CAS No.: 1185159-32-3
• Molecular Formula: C₅₀H₇₄O₁₆S
• Molecular Weight: 963.194
• Mol file: 1185159-32-3.mol

Synonyms:C₅₀H₇₄O₁₆S

Chemical Property of C₅₀H₇₄O₁₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₇₄O₁₆S

There total 5 articles about C₅₀H₇₄O₁₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

C50H74O16S → C50H74O16S (1185159-32-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 3h; Inert atmosphere; Ice cooling;

Reference yield:

6-O-methylerythromycin A N-oxide (118074-07-0) → C50H74O16S (1185159-32-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 2 h / 160 - 180 °C / 0.53 Torr / Neat (no solvent)

2.1: dmap / dichloromethane / 32 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -50 °C

3.2: 5.58 h / -50 - 3 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24 h / 100 °C

5.1: pyridine; dmap / dichloromethane / 20 °C / Inert atmosphere

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide / acetone / 18 h / 20 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 5 °C / Inert atmosphere; Ice cooling

With pyridine; dmap; sodium hexamethyldisilazane; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; mineral oil;

Reference yield:

C36H62O13 (1185159-19-6) → C50H74O16S (1185159-32-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dmap / dichloromethane / 32 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -50 °C

2.2: 5.58 h / -50 - 3 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24 h / 100 °C

4.1: pyridine; dmap / dichloromethane / 20 °C / Inert atmosphere

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide / acetone / 18 h / 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 5 °C / Inert atmosphere; Ice cooling

With pyridine; dmap; sodium hexamethyldisilazane; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; mineral oil;

upstream raw materials:

6-O-methylerythromycin A N-oxide

C₃₆H₆₂O₁₃

clarithromycin

Refernces