2-(3,3-Diphenylpropylamino)acetamide

Base Information

• Chemical Name: 2-(3,3-Diphenylpropylamino)acetamide
• CAS No.: 76991-05-4
• Molecular Formula: C₁₇H₂₀N₂O
• Molecular Weight: 268.359
• DSSTox Substance ID: DTXSID50587876
• Wikidata: Q27164489
• ChEMBL ID: CHEMBL1255662
• Mol file: 76991-05-4.mol

Synonyms:76991-05-4;N-(3,3-Diphenylpropyl)glycinamide;2-(3,3-diphenylpropylamino)acetamide;2-[(3,3-Diphenylpropyl)amino]acetamide;N20C;2-((3,3-Diphenylpropyl)amino)acetamide;Acetamide, 2-[(3,3-diphenylpropyl)amino]-;NCGC00015378-01;Lopac-D-8816;Lopac0_000489;MLS002153222;2-amino-N-(3,3-diphenylpropyl)acetamide hydrochloride;SCHEMBL1321258;CHEMBL1255662;CHEBI:92727;DTXSID50587876;HMS2233E15;HMS3261B19;HMS3373I06;BCP32392;Tox21_500489;MFCD12828862;AKOS028108784;CCG-204580;LP00489;SDCCGSBI-0050473.P002;NCGC00015378-03;NCGC00015378-04;NCGC00015378-05;NCGC00092339-02;NCGC00092339-03;NCGC00261174-01;AS-44320;SMR001230694;EU-0100489;D 8816;SR-01000075891;SR-01000075891-1;BRD-K41143549-003-01-6;Q27164489;N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid

Chemical Property of 2-(3,3-Diphenylpropylamino)acetamide

Chemical Property:

• Vapor Pressure: 3.61E-10mmHg at 25°C
• Boiling Point: 494.7°C at 760 mmHg
• Flash Point: 253°C
• PSA: 55.12000
• LogP: 4.17670
• Storage Temp.: −20°C
• Solubility.: DMSO: 26 mg/mL, soluble
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 268.157563266
• Heavy Atom Count: 20
• Complexity: 263

Purity/Quality:

98%Min ^*data from raw suppliers

N20C hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CCNCC(=O)N)C2=CC=CC=C2
• Uses: N20C is a non-competitive NMDA receptor open-channel blocker.

Technology Process of 2-(3,3-Diphenylpropylamino)acetamide

There total 2 articles about 2-(3,3-Diphenylpropylamino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-diphenylpropyl amine (5586-73-2) + chlorbetamide (97-27-8) → 3,3-diphenylpropyl-N-glycinamide (76991-05-4)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 90 ℃; for 24h;

DOI:10.1124/jpet.302.1.163

Reference yield:

3-diphenylpropyl amine (5586-73-2) + bromoacetic acid (79-08-3) → 3,3-diphenylpropyl-N-glycinamide (76991-05-4)

Guidance literature:

bromoacetic acid; With diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

3-diphenylpropyl amine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

With water; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/cbic.201500169

upstream raw materials:

3-diphenylpropyl amine

chlorbetamide

bromoacetic acid

Refernces

• 1、 Vendrell-Navarro, Glòria,Rúa, Federico,Bujons, Jordi,Brockmeyer, Andreas,Janning, Petra,Ziegler, Slava,Messeguer, Angel,Waldmann, Herbert. "Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin". . p. 1580 - 1587. Retrieved 2015.