1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate

Base Information

• Chemical Name: 1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate
• CAS No.: 610785-96-1
• Molecular Formula: C₁₆H₂₂O₄S
• Molecular Weight: 310.414
• Mol file: 610785-96-1.mol

Synonyms:1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate

Chemical Property of 1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate

There total 3 articles about 1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-isopropoxyacetic acid (33445-07-7) + 2-hydroxy-2-methyl-1-(4-(methylthio)phenyl)-propan-1-one (71867-98-6) → 1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate (610785-96-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 25 ℃;

DOI:10.1016/j.tet.2003.08.021

Reference yield:

isopropyl 2-isopropoxyacetate (17639-74-6) → 1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate (610785-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NaOH / methanol; H₂O / 1 h / 25 °C

2: 75 percent / 4-dimethylaminopyridine; 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 25 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water;

DOI:10.1016/j.tet.2003.08.021

Reference yield:

2-methyl-1-(4-(methylthio)phenyl)-propan-1-one (53207-58-2) → 1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate (610785-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Aliquat 366; carbon tetrachloride; NaOH / toluene / 22 h / 15 - 25 °C

2: 75 percent / 4-dimethylaminopyridine; 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 25 °C

With tetrachloromethane; dmap; sodium hydroxide; aliquat 366; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1016/j.tet.2003.08.021

upstream raw materials:

2-isopropoxyacetic acid

2-hydroxy-2-methyl-1-(4-(methylthio)phenyl)-propan-1-one

isopropyl 2-isopropoxyacetate

2-methyl-1-(4-(methylthio)phenyl)-propan-1-one

Downstream raw materials:

5,5-dimethyl-4-(4-methylsulfonylphenyl)-3-(2-propoxy)-5H-furan-2-one

3-isopropoxy-5,5-dimethyl-4-(4-methylsulfanylphenyl)-2,5-dihydro-2-furanone

Refernces