4-(p-methoxyphenyl)-3-butenoic acid

Base Information

• Chemical Name: 4-(p-methoxyphenyl)-3-butenoic acid
• CAS No.: 91142-97-1
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Mol file: 91142-97-1.mol

Synonyms:4-(p-methoxyphenyl)-3-butenoic acid

Chemical Property of 4-(p-methoxyphenyl)-3-butenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(p-methoxyphenyl)-3-butenoic acid

There total 10 articles about 4-(p-methoxyphenyl)-3-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-carboxyethyl)triphenylphosphonium bromide (51114-94-4) + 4-methoxy-benzaldehyde (123-11-5) → 4-(p-methoxyphenyl)-3-butenoic acid (91142-97-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.9b04619

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 3-(p-methoxyphenyl)-2-propen-1-yl methyl carbonate (488151-80-0) → 2-(p-methoxyphenyl)-3-butenoic acid (131330-74-0) + 4-(p-methoxyphenyl)-3-butenoic acid (91142-97-1)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In acetonitrile; at 0 ℃; under 760.051 Torr; Electrochemical reaction;

DOI:10.1016/j.tet.2010.07.067

Reference yield:

C23H38O3Sn → 4-(p-methoxyphenyl)-3-butenoic acid (91142-97-1)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 0.25h;

DOI:10.1081/SCC-200032474

upstream raw materials:

2-hydroxy-4-(4-methoxyphenyl)but-3-enoic acid

sodium succinate

4-methoxy-benzaldehyde

acetic anhydride

Downstream raw materials:

4-(4-Methoxyphenyl)butyric acid

(E)-methyl 2-diazo-4-(4-methoxyphenyl)but-3-enoate

7-Methoxy-1-tetralone

3-(4-methoxybenzoyl)acrylic acid

Refernces

• 1、 Chen, Yuzhen,Huang, Huicai,Ma, Yan-Yan,Wang, Shuzhong,Wang, Yichen,Zhan, Ruoting,Zhao, Deng-Gao. "Asymmetric Construction of Cyclobutanes via Direct Vinylogous Michael Addition/Cyclization of β,γ-Unsaturated Amides". supporting information. p. 7135 - 7140. Retrieved 2020/10/12.
• 2、 Vercouillie, Johnny,Abarbri, Mohamed,Parrain, Jean-Luc,Duchene, Alain,Thibonnet, Jerome. "Synthesis of 1-tetralone derivatives using a Stille cross coupling/friedel crafts acylation sequence". . p. 3751 - 3762. Retrieved 2007/10/03.