2-(2-Aminoethyl)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-(2-Aminoethyl)isoindoline-1,3-dione
• CAS No.: 71824-24-3
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.202
• Hs Code.: 2925190090
• DSSTox Substance ID: DTXSID00361567
• Nikkaji Number: J710.732C
• Wikidata: Q72436881
• ChEMBL ID: CHEMBL2385930
• Mol file: 71824-24-3.mol

Synonyms:71824-24-3;2-(2-Aminoethyl)isoindoline-1,3-dione;N-(2-Amino-ethyl)-phthalimide;2-(2-aminoethyl)isoindole-1,3-dione;2-(2-aminoethyl)-1H-isoindole-1,3(2H)-dione;N-[2-Aminoethyl]phthalimide;2-(2-aminoethyl)-2,3-dihydro-1H-isoindole-1,3-dione;N-(2-Aminoethyl)phthalimide;Oprea1_337184;N-(2-Amino-ethyl)phthalimide;SCHEMBL1309018;CHEMBL2385930;DTXSID00361567;WCA82424;STK273548;AKOS000154502;SB38436;2-(2-azanylethyl)isoindole-1,3-dione;2-(2-aminoethyl) isoindoline-1,3-dione;BB 0218467;FT-0650304;EN300-58571;A837336;F1265-0007

Chemical Property of 2-(2-Aminoethyl)isoindoline-1,3-dione

Chemical Property:

• Vapor Pressure: 0.000111mmHg at 25°C
• Melting Point: 192℃
• Refractive Index: 1.619
• Boiling Point: 336.6 °C at 760 mmHg
• Flash Point: 157.4 °C
• PSA: 63.40000
• Density: 1.322 g/cm³
• LogP: 0.87950
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 190.074227566
• Heavy Atom Count: 14
• Complexity: 241

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Amino-ethyl)-phthalimide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41-51
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)CCN
• Uses: N-(2-Amino-ethyl)-phthalimide is used in preparation of aluminum complexes containing Salicylaldehyde group and its application as catalyst of cyclic lactone ring-opening polymerization.

Technology Process of 2-(2-Aminoethyl)isoindoline-1,3-dione

There total 19 articles about 2-(2-Aminoethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phthalic anhydride (85-44-9) + ethylenediamine (107-15-3,85404-18-8) → 2-(2-aminoethyl)-1H-isoindole-1,3(2H)-dione (71824-24-3)

Guidance literature:

With acetic acid; at 100 ℃; for 1h;

DOI:10.1016/j.ejmech.2009.03.006

Reference yield: 91.0%

2,2-di-para-methoxyphenyl-1,3-indanedione (66064-61-7) + ethylenediamine (107-15-3,85404-18-8) → 2-(2-aminoethyl)-1H-isoindole-1,3(2H)-dione (71824-24-3) + 4,4'-dianisylmethane (726-18-1)

Guidance literature:

for 0.0333333h; microwave irradiation;

Reference yield: 90.0%

ethylenediamine (107-15-3,85404-18-8) + 2,2-Bis-(4-chloro-phenyl)-indan-1,3-dione (208588-16-3) → 2-(2-aminoethyl)-1H-isoindole-1,3(2H)-dione (71824-24-3) + 4,4'-dichlorodiphenylmethane (101-76-8)

Guidance literature:

for 0.0333333h; microwave irradiation;

upstream raw materials:

2,2-diphenyl-1,3-indanedione

ethylenediamine

2,2-di-para-methoxyphenyl-1,3-indanedione

2,2-Bis-(4-fluoro-phenyl)-indan-1,3-dione

Refernces

• 1、 Kumar, Palanichamy Santhosh,Kumar, Kuruba Bharath,Obadiah, Asir,Kumar, Suluvoy Jagadish,Mohanapriya, Raman,Durairaj, Arulappan,Ramanathan, Subramanian,Vasanthkumar, Samuel. "Synthesis, molecular docking, cytotoxicity and antioxidant activity evaluation of isoindoline-1,3-dione derivatives". . p. 2548 - 2556. Retrieved 2019/10/02.
• 2、 -. "Asymmetric ligand containing acetylacetone derivative as well as preparation method and application thereof". Paragraph 0034. . Retrieved 2018/06/15.